Essential biopharmaceutical properties of drugs at the gastrointestinal absorption stage (Review)
The essential biopharmaceutical properties affecting the ability of drugs to reach the systemic circulation are discussed. Properties such as biopharmaceutical solubility and intestinal permeability are described, along with methods of assessing them and interactions between drug transport and absorption across GIT membranes and levels of metabolism. The main biopharmaceutical classification systems for drugs are presented and their use in regulatory practice is discussed.
Key wordsSolubility absorption permeability metabolism biopharmarceutical classification system (BCS) biopharmaceutical drug disposition classification system (BDDCS) based on solubility and metabolism biowaiver
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