Pharmaceutical Chemistry Journal

, Volume 44, Issue 11, pp 594–596 | Cite as

Synthesis and analgesic and anti-inflammatory activities of (2Z,5Z)-1-aryl-3-hydroxy-5-(3,3-dialkyl-3,4-dihydroisoquinolin-1(2H)-yliden)pent-2-en-1,4-diones

  • V. V. Khalturina
  • Yu. V. Shklyaev
  • R. R. Makhmudov
  • A. N. Maslivets

5-Arylfuran-2,3-diones and (Z)-alkyl-4-aryl-2-hydroxy-4-oxobut-2-enoates react with 3,3-dialkyl-1-methyl-3,4-dihydroxyisoquinolines to form (2Z,5Z)-1-aryl-3-hydroxy-5-(3,3-dialkyl-3,4-dihydroxyisoquinolin-1(2H)-yliden)pent-2-en-1,4-diones which have analgesic and anti-inflammatory activities.

Key words

5-Arylfuran-2,3-diones aroylpyruvic acids 1-methyl-3,4-dihydroisoquinolines analgesic and anti-inflammatory activity 


This study was supported financially by the Russian Foundation for Basic Research (Grant No. 08-03-01032).


  1. 1.
    Yu. S. Andreichikov, V. S. Shklyaev, B. B. Aleksandrov, et al., Khim. Geterotsikl. Soedin., 420 (1982).Google Scholar
  2. 2.
    Yu. V. Shklyaev and A. N. Maslivets, Zh. Organ. Khim., 32, 319 (1996).Google Scholar
  3. 3.
    V. V. Khalturina, Yu. V. Shklyaev, Z. G. Aliev, and A. N. Maslivets, Zh. Organ. Khim., 5, 743 (2009).Google Scholar
  4. 4.
    N. B. Eddy and D. J. Leimbarh, Pharmacol. Exper. Ther., 385 (1953).Google Scholar
  5. 5.
    Guidelines for Experimental Preclinical Studies of Nonsteroidal Anti-inflammatory Drugs [in Russian], Moscow (1982).Google Scholar
  6. 6.
    L. Belen’kii, Elements of Quantitative Measurements of Pharmacological Effects [in Russian], Meditsinskaya Literatura, Leningrad (1963).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. V. Khalturina
    • 1
  • Yu. V. Shklyaev
    • 1
  • R. R. Makhmudov
    • 2
  • A. N. Maslivets
    • 2
  1. 1.Institute of Technical Chemistry, Urals BranchRussian Academy of SciencesPermRussia
  2. 2.Natural Sciences InstitutePerm State UniversityPermRussia

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