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Pharmaceutical Chemistry Journal

, Volume 44, Issue 10, pp 542–550 | Cite as

Synthesis and antimicrobial activity of chalcone derivatives of indole nucleus

  • R. Chauhan
  • J. Dwivedi
  • A. A. Siddiqi Anees
  • D. Kishore
Article

A series of previously unreported (2Z)-2-(1H-indol-1-yl)-3-(4-substituted phenyl)-1-phenylprop-2-en-1-one (5a–d) have been synthesized from easily accessible 2-(1H-indol-1-yl)-1-phenylethanone (3), which was obtained via a reaction of indole (1) with chloromethylphenyl ketone (2). The structures of the synthesized products have been elucidated using IR, 1H NMR, and mass-spectroscopic data and elemental analyses. The final products were screened for their antimicrobial activity. Excellent results were obtained against both bacteria and fungi. In conclusion, we have developed a novel, convenient and simple method for the preparation of indole – chalcone hybrid compounds via the reaction of indole derivative with carbonyl compounds in the presence of a strong base. The rapid conversion, excellent yield, utilization of a base, and operational simplicity are great advantages of the proposed method.

Key words

Mannich reaction chalcone indole derivatives antimicrobial activity 

Notes

Acknowledgements

The authors are thankful to V. C. Banasthali University (Rajasthan) and Jamia Hamdard University (Delhi) for providing the spectral and analytical data. This paper is a part of Ph. D. Thesis of Rajani Chauhan.

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • R. Chauhan
    • 2
  • J. Dwivedi
    • 3
  • A. A. Siddiqi Anees
    • 1
  • D. Kishore
    • 2
  1. 1.Department of PharmacyBanasthali UniversityTonkIndia
  2. 2.Department of ChemistryBanasthali UniversityTonkIndia
  3. 3.Department of PharmacyJamia Hamdard UniversityNew DelhiIndia

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