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Pharmaceutical Chemistry Journal

, Volume 44, Issue 10, pp 528–529 | Cite as

Synthesis and immunomodulating properties of poly(N-vinylformamide)

  • E. F. Panarin
  • N. A. Nesterova
  • I. I. Gavrilova
  • N. P. Ivanova
  • A. T. Belokhvostova
  • L. S. Potapenkova
Article

A series of poly(N-vinylformamide) (PNVF) samples with molecular masses in the range (8.7 – 280) × 103 were synthesized. The effect of the polymer molecular mass on the PNVF-stimulated antibody response was investigated using BALB/C mice (Rappolovo nursery). The immunostimulating activity of the polymer was estimated by its influence on the appearance of antibody-forming cells to sheep red blood cells by the local hemolysis method in gel. A strong dependence of the antibody response on the polymer molecular mass was observed. The maximum activity was manifested for PNVF with molecular masses in the range (55 – 85) × 103.

Key words

poly(N-vinylformamide) immunostimulating activity 

References

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    Immunology Methods [in Russian], Meditsina, Moscow (1987), pp.57 –72.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • E. F. Panarin
    • 1
  • N. A. Nesterova
    • 1
  • I. I. Gavrilova
    • 1
  • N. P. Ivanova
    • 1
  • A. T. Belokhvostova
    • 2
  • L. S. Potapenkova
    • 2
  1. 1.Institute of Macromolecular CompoundsRussian Academy of SciencesSt. PetersburgRussia
  2. 2.Petrov Institute of OncologyMinistry of Public Health of the Russian FederationSt. PetersburgRussia

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