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Chemical and biological investigation of hydrolysate based on lactic-acid bacterial cultures

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Pharmaceutical Chemistry Journal Aims and scope

The amino-acid and elemental composition of a hydrolysate based on lactic-acid bacterial cultures has been studied. The quantitative content of amino acids in the hydrolysate is determined and the analytical method is validated with respect to linearity, reproducibility, and accuracy. Investigation of the biological activity of the hydrolysate by three-day cultivation with cells showed evidence for stimulation of the expression of T-lymphocytes (CD3+) and their subpopulation with helper activity (CD4+).

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References

  1. A. Yu. Lopatina, M. S. Blyakher, V. N. Nikolaenko, et al., Vestn. Ross. Akad. Med. Nauk, No. 3, 30 – 34 (1987).

  2. V. M. Bondarenko, E. I. Rubakova, and V. A. Lavrova, Zh. Mikrobiol., No. 5, 107 – 112 (1998).

  3. V. A. Samoilov, N. M. Gostishcheva, G. V. Sen’chukova, et al., Khim.-farm. Zh., 39(3), 51 – 53 (2005).

    Google Scholar 

  4. A. B. Kuznetsova, Author’s Abstract of a Candidate Dissertation in Medical Sciences, Ulan-Ude (2007).

  5. A. V. Filatov, G. S. Bachurin, N. A. Markova, et al., Gematol. Transfuziol., 35(4), 16 – 19 (1990).

    CAS  PubMed  Google Scholar 

  6. GOST R. ISO 5725-1-2002. Correctness (Accuracy and Precision) of Measurement Methods and Results. Part 1. Principles and Determinations, IPK Izd. Standartov, Moscow (2002).

  7. GOST R. ISO 5725-4-42003. Correctness (Accuracy and Precision) of Measurement Methods and Results. Part 4. Principal Methods for Determining the Accuracy of Standard Measurement Methods, IPK Izd. Standartov, Moscow (2002).

  8. Development Pharmaceucs and Process Validation, Directive 75318EE c. (1998).

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Authors and Affiliations

  1. Pyatigorsk State Pharmaceutical Academy, Pyatigorsk, Russia

    G. S. Garanyan & E. T. Oganesyan

  2. Kuban State Medical University, Krasnodar, Russia

    R. A. Khanferyan

Authors
  1. G. S. Garanyan
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  2. R. A. Khanferyan
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  3. E. T. Oganesyan
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 8, pp. 46 – 49, August, 2010.

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Garanyan, G.S., Khanferyan, R.A. & Oganesyan, E.T. Chemical and biological investigation of hydrolysate based on lactic-acid bacterial cultures. Pharm Chem J 44, 459–462 (2010). https://doi.org/10.1007/s11094-010-0490-x

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  • DOI: https://doi.org/10.1007/s11094-010-0490-x

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