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Pharmaceutical Chemistry Journal

, Volume 44, Issue 8, pp 427–429 | Cite as

Synthesis and antimicrobial activity of dialkyl-2-aryl-6-hydroxy-6-methyl-4-( p-toluenesulfonylaminoimino) cyclohexane-1,3-dicarboxylates

  • V. L. Gein
  • A. S. Prusakova
  • N. V. Nosova
  • M. I. Vakhrin
  • E. V. Voronina
  • A. P. Kriven’ko
Article

Reaction of dialkyl-2-aryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxylates with tosylhydrazide proceeds via the alicyclic carbonyl group to give dialkyl-2-aryl-6-hydroxy-6-methyl-4-(p-toluenesulfonylaminoimino) cyclohexane-1,3-dicarboxylates. The antimicrobial activity of the synthesized compounds has been evaluated.

Key words

synthesis antimicrobial activity dialkyl-2-aryl-6-hydroxy-6-methyl-4-(p-toluenesulfonylaminoimino) cyclohexane-1,3-dicarboxylates 

Notes

Acknowledgments

The work was supported financially by the RFBR Project No. 04-03-96042.

References

  1. 1.
    V. L. Gein, A. A. Zorina, N. V. Gein, et al., Khim.-farm. Zh., 39(4), 21–23 (2005).Google Scholar
  2. 2.
    V. L. Gein, N. V. Gein, E. V. Voronina, et al., Khim.-farm. Zh., 36(3), 23–26 (2002).Google Scholar
  3. 3.
    V. L. Gein, N. V. Nosova, K. D. Potemkin, et al., Zh. Org. Khim., 41(7), 1039–1045 (2005).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. L. Gein
    • 1
  • A. S. Prusakova
    • 1
  • N. V. Nosova
    • 1
  • M. I. Vakhrin
    • 1
  • E. V. Voronina
    • 1
  • A. P. Kriven’ko
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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