Advertisement

Pharmaceutical Chemistry Journal

, Volume 44, Issue 7, pp 396–400 | Cite as

Developing analytical methods for afobazole in injection forms

  • L. N. Grushevskaya
  • N. I. Avdyunina
  • S. E. Milkina
  • O. B. Stepanenko
  • B. M. Pyatin
  • K. V. Alekseev
  • S. A. Sizyakov
STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL
  • 32 Downloads

This investigation was aimed at elaborating procedures for the pharmaceutical analysis of the parenteral dosage form of afobazole, a novel domestic drug with anxiolytic and neuroprotective action. The physicochemical properties of afobazole parenteral dosage form have been studied. Methods for the determination of impurities (TLC, HPLC) and identification and assay of the drug (UV spectrophotometry, HPLC) have been developed.

Key words

afobazole parenteral dosage form pharmaceutical analysis thin-layer chromatography high performance liquid chromatography 

References

  1. 1.
    S. B. Seredenin, Yu. A. Blednov, V. L. Savel’ev, et al., RF Pat. No. 2,061,686; Byull. Izobret., No. 16 (1996).Google Scholar
  2. 2.
    I. P. Galaeva, T. L. Garibova, T. A.Voronina, and S. B. Seredenin, Byull. Eksp. Biol. Med., 140(11), 545 – 548 (2005).Google Scholar
  3. 3.
    S. E. Milkina, O. B. Stepanenko, L. N. Grushevskaya, et al., Khim.-farm. Zh., 40(7), 55 – 56 (2006).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • L. N. Grushevskaya
    • 1
    • 2
  • N. I. Avdyunina
    • 1
    • 2
  • S. E. Milkina
    • 1
    • 2
  • O. B. Stepanenko
    • 1
    • 2
  • B. M. Pyatin
    • 1
    • 2
  • K. V. Alekseev
    • 1
    • 2
  • S. A. Sizyakov
    • 1
    • 2
  1. 1.Zakusov Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.Institute for Drug Standardization, State Scientific Center for Drug Expertise and ControlMinistry of Public Health of the Russian FederationMoscowRussia

Personalised recommendations