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Pharmaceutical Chemistry Journal

, Volume 44, Issue 7, pp 366–369 | Cite as

Synthesis and antimicrobial activity of n,7-diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a] pyrimidine-6-arboxamides

  • V. L. Gein
  • T. M. Zamaraeva
  • A. A. Kurbatova
  • E. V. Voronina
  • M. I. Vakhrin
Article

N,7-Diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamides were synthesized by three-component reaction of acetoacetanilides (2-methylacetoacetanilide, 2,4-dimethylacetoacetanilide, 4-chloroacetoacetanilide, o-acetoacetanilide) with a mixture of aromatic aldehyde and 5-aminotetrazole. The proposed structures are confirmed by IR and PMR spectroscopy and mass spectrometry. The synthesized compounds are characterized with respect to antimicrobial activity.

Key words

N,7-Diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a] pyrimidine-6-carboxamides synthesis antimicrobial activity 

References

  1. 1.
    V. L. Gein, E. B. Levandovskaya, N. V. Nosova, et al., Zh. Org. Khim., 43, 1101 (2007).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. L. Gein
    • 1
  • T. M. Zamaraeva
    • 1
  • A. A. Kurbatova
    • 1
  • E. V. Voronina
    • 1
  • M. I. Vakhrin
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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