Synthesis and antimicrobial activity of n,7-diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a] pyrimidine-6-arboxamides
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N,7-Diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamides were synthesized by three-component reaction of acetoacetanilides (2-methylacetoacetanilide, 2,4-dimethylacetoacetanilide, 4-chloroacetoacetanilide, o-acetoacetanilide) with a mixture of aromatic aldehyde and 5-aminotetrazole. The proposed structures are confirmed by IR and PMR spectroscopy and mass spectrometry. The synthesized compounds are characterized with respect to antimicrobial activity.
Key wordsN,7-Diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a] pyrimidine-6-carboxamides synthesis antimicrobial activity
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