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Pharmaceutical Chemistry Journal

, Volume 44, Issue 6, pp 319–323 | Cite as

Potential carriers for controlled drug release based on interpolyelectrolyte complexes using Eudragit® types EPO and L100-55. I. Synthesis and comparative physicochemical evaluation

  • R. I. Mustafin
  • O. L. Bobyleva
  • V. L. Bobyleva
  • G. Van den Mooter
  • V. A. Kemenova
Article

New interpolyelectrolyte complexes (IPEC) between oppositely charged types of Eudragit®, EPO and L100-55, with different molar ratios were synthesized with the aim of seeking potential carriers for oral delivery systems. Elemental analysis showed that the resulting polycomplexes had different compositions, with 0.36 < Z = [EPO]/[L100] < 1.81. The structural properties of the materials assessed by IR spectroscopy and modulated-temperature differential scanning calorimetry showed that all IPEC were stabilized by a cooperative system of ionic bonds, were chemically homogeneous, and were characterized by the presence of a single glass transition temperature. These properties suggest that the polycomplexes synthesized here have potential for further study as carriers for controlled drug release in specified parts of the gastrointestinal tract.

Key words

Eudragit® EPO and L100-55 interpolyelectrolyte complexes synthesis physicochemical properties 

References

  1. 1.
    B. Skalsky and H.-U. Petereit, in: Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, J. W. McGinity and L. A. Felton (Eds.), Informa Healthcare, New York (2008), pp. 237 – 279.Google Scholar
  2. 2.
    R. I. Mustafin and T. V. Kabanova, Khim.-Farm. Zh., 38(11), 39 – 41 (2004).Google Scholar
  3. 3.
    R. I. Mustafin and T. V. Kabanova, Khim.-Farm. Zh., 39(2), 34 – 38 (2005).Google Scholar
  4. 4.
    R. I. Moustafine, T. V. Kabanova, V. A. Kemenova, and G. Van den Mooter, J. Control. Rel., 103, 191 – 198 (2005).CrossRefGoogle Scholar
  5. 5.
    R. I. Moustafine, Proc. 5th World Meeting (APV & APGI) on Pharm. Biopharm. & Pharm. Technol., Geneva (2006), Abstr. 17.Google Scholar
  6. 6.
    R. I. Moustafine and O. L. Bobyleva, Proc. 5th World Meeting (APV & APGI) on Pharm. Biopharm. & Pharm. Technol., Geneva (2006), Abstr. 20.Google Scholar
  7. 7.
    R. I. Moustafine and O. L. Bobyleva, J. Control. Rel., 116(2), e35 – e36 (2006).CrossRefGoogle Scholar
  8. 8.
    R. I. Moustafine, I. M. Zaharov, and V. A. Kemenova, Eur. J. Pharm. Biopharm., 63, 26 – 36 (2006).CrossRefPubMedGoogle Scholar
  9. 9.
    A. R. Menjoge and M. G. Kulkarni, Int. J. Pharm., 343, 106 – 121 (2007).CrossRefPubMedGoogle Scholar
  10. 10.
    W. M. Obeidat, A. H. Abu Znait, and A. A. Sallam, Drug Dev. Ind. Pharm., 34, 650 – 660 (2008).CrossRefPubMedGoogle Scholar
  11. 11.
    Y. Zhang, L. Hu, Y. Min, et al., Eur. Polym. J., 42, 2959 – 2967 (2006).CrossRefGoogle Scholar
  12. 12.
    S. Qi, A. Gryczke, P. Belton, and D. Q. M. Craig, Int. J. Pharm., 354, 158 – 167 (2007).CrossRefPubMedGoogle Scholar
  13. 13.
    J. Albers, R. Alles, K. Matthée, et al., Eur. J. Pharm. Biopharm., 71, 387 – 394 (2009).CrossRefPubMedGoogle Scholar
  14. 14.
    K. A. Mehta, M. S. Kislalioglu, W. Phuapradit, et al., Int. J. Pharm., 213,7–12 (2001).CrossRefPubMedGoogle Scholar
  15. 15.
    D. Sauer, A. B. Watts, L. B. Coots, et al., Int. J. Pharm., 367, 20 – 28 (2009).CrossRefPubMedGoogle Scholar
  16. 16.
    D. Sauer and J. W. McGinity, Pharm. Dev. Technol., 16(6), 632 – 641 (2009).CrossRefGoogle Scholar
  17. 17.
    S. Gordon and J. S. Taylor, J. Appl. Chem., 2, 493 – 500 (1952).CrossRefGoogle Scholar
  18. 18.
    R. Simha and R. F. Boyer, J. Chem. Phys., 37, 1003 (1962).CrossRefGoogle Scholar
  19. 19.
    D. Gallardo, B. Skalsky, and P. Kleinebudde, Pharm. Dev. Technol., 13(5), 413 – 423 (2008).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • R. I. Mustafin
    • 1
  • O. L. Bobyleva
    • 1
  • V. L. Bobyleva
    • 1
  • G. Van den Mooter
    • 2
  • V. A. Kemenova
    • 3
  1. 1.Kazan State Medical UniversityKazanRussia
  2. 2.Leuven Catholic UniversityLeuvenBelgium
  3. 3.All-Russian Institute of Medicinal and Aromatic Plants (VILAR)MoscowRussia

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