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Pharmaceutical Chemistry Journal

, Volume 44, Issue 6, pp 296–298 | Cite as

Synthesis and antifungal activity of 3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]isoquinolinecarboxylic acid amides

  • O. V. Surikova
  • A. G. Mikhailovskii
  • N. N. Pershina
  • G. A. Aleksandrova
  • V. V. Semeriko
  • M. I. Vakhrin
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Reaction of enaminoamides of the 1,2,3,4-tetrahydroisoquinoline series with p-benzoquinone yielded 3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]-isoquinolinecarboxylic acid amides. Use of benzo[f]isoquinoline as the enamine resulted in synthesis of the relatively unknown benzo[f]indolo[2,1-a]isoquinoline system. The fungicidal activity of the compounds synthesized here was studied and the most active was the hexamethyleneimide, which was active at a concentration of 500 μg/ml.

Key words

Synthesis 3-hydroxy-7,7-dialkyl-7,8-dihydroindolo[2,1-a]-isoquinolinecarboxylic acid amides antifungal activity 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • O. V. Surikova
    • 1
    • 2
  • A. G. Mikhailovskii
    • 1
    • 2
  • N. N. Pershina
    • 1
    • 2
  • G. A. Aleksandrova
    • 1
    • 2
  • V. V. Semeriko
    • 1
    • 2
  • M. I. Vakhrin
    • 1
    • 2
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Natural Sciences InstitutePerm State UniversityPermRussia

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