Diffusion-transport properties of a polycomplex matrix system based on eudragit® EPO and Carbomer 940
New interpolyelectrolyte complexes (IPEC) between Eudragit® EPO (EPO) and Carbomer 940 (C940) were synthesized for assessment as controlled-release delivery carriers for oral systems. Depending on the structural properties, the resulting IPEC were distinct from the individual (co)polymers and their physical mixtures in terms of their swelling profiles in media simulating the gastrointestinal tract. Changes in structure and composition occurring within the polycomplex matrix on swelling were studied by IR spectroscopy, MT-DSC (modulated temperature differential scanning calorimetry), and elemental analysis. The mechanism underlying the transport of the model drug ibuprofen from the polycomplex matrix was identified.
Key wordsPolycomplex controlled release ibuprofen Eudragit® Carbomer 940
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