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Pharmaceutical Chemistry Journal

, Volume 44, Issue 1, pp 1–6 | Cite as

Inverse agonists of H1-receptors as promising antiallergy agents (a review)

  • I. S. Gushchin
Molecular-biological problems of drug design and mechanism of drug action

The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonists of H1-receptors and features of the receptor–ligand interaction that maintain H1-receptors in the non-active state are considered. The broadening of clinical indications for the administration of inverse agonists of H1-receptors aimed at preventing the exacerbation of allergic (atopic) disorders and inhibiting allergic inflammation processes is justified.

Key words

second generation H1-antihistamine drugs H1-receptors inverse agonists NF-κB antiallergic effect 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • I. S. Gushchin
    • 1
  1. 1.Institute of Immunology, Federal Medico-Biological AgencyMinistry of Public Health and Social Development of the Russian FederationMoscowRussia

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