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Pharmaceutical Chemistry Journal

, Volume 43, Issue 11, pp 625–631 | Cite as

Solubility of erythromycin from solid dispersions

  • R. U. Khabriev
  • V. A. Popkov
  • V. Yu. Reshetnyak
  • I. I. KrasnyukJr
  • A. S. Lapshova
Article

The effect of solid dispersion (SD) formation on the solubility of the antibiotic erythromycin has been studied using the parent substance of erythromycin and its SDs with polyethyleneglycol (PEG-1500), polyvinylpyrrolidone (PVP-10000), and β-cyclodextrin. It is established that SD formation increases the solubility of the antibiotic by a factor of 1.3 – 1.8; the dissolution rate, 1.5 – 2.0. Results using a complex of physical and chemical methods suggest that the increase in erythromycin release from SDs takes place due to a decrease in the degree of crystallinity and the formation of intermolecular complexes.

Key words

erythromycin solid dispersions effect on solubility 

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References

  1. 1.
    R. U. Khabriev, V. G. Kukes, A. P. Arzamastsev (ed.), et al., Antibacterial Drugs. Standardization Methods of Preparations [in Russian], Meditsina, Moscow (2004), pp. 94 – 101.Google Scholar
  2. 2.
    I. I. Krasnyuk, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2003).Google Scholar
  3. 3.
    I. I. Krasnyuk, Jr., V. A. Popkov, V. Yu. Reshetnyak, et al., Ross. Med. Zh., No. 6, 34 – 37 (2005).Google Scholar
  4. 4.
    Yu. V. Skovpen(, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2002).Google Scholar
  5. 5.
    G. S. Babakina, G. P. Gaidukova, A. E. Gulyaev, et al., Khim.-farm. Zh., 25(4), 62 – 65 (1991).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • R. U. Khabriev
    • 1
  • V. A. Popkov
    • 1
  • V. Yu. Reshetnyak
    • 1
  • I. I. KrasnyukJr
    • 1
  • A. S. Lapshova
    • 1
  1. 1.Sechenov Medical AcademyMoscowRussia

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