Solubility of erythromycin from solid dispersions
- 132 Downloads
The effect of solid dispersion (SD) formation on the solubility of the antibiotic erythromycin has been studied using the parent substance of erythromycin and its SDs with polyethyleneglycol (PEG-1500), polyvinylpyrrolidone (PVP-10000), and β-cyclodextrin. It is established that SD formation increases the solubility of the antibiotic by a factor of 1.3 – 1.8; the dissolution rate, 1.5 – 2.0. Results using a complex of physical and chemical methods suggest that the increase in erythromycin release from SDs takes place due to a decrease in the degree of crystallinity and the formation of intermolecular complexes.
Key wordserythromycin solid dispersions effect on solubility
Unable to display preview. Download preview PDF.
- 1.R. U. Khabriev, V. G. Kukes, A. P. Arzamastsev (ed.), et al., Antibacterial Drugs. Standardization Methods of Preparations [in Russian], Meditsina, Moscow (2004), pp. 94 – 101.Google Scholar
- 2.I. I. Krasnyuk, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2003).Google Scholar
- 3.I. I. Krasnyuk, Jr., V. A. Popkov, V. Yu. Reshetnyak, et al., Ross. Med. Zh., No. 6, 34 – 37 (2005).Google Scholar
- 4.Yu. V. Skovpen(, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2002).Google Scholar
- 5.G. S. Babakina, G. P. Gaidukova, A. E. Gulyaev, et al., Khim.-farm. Zh., 25(4), 62 – 65 (1991).Google Scholar