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Synthesis, antiherpes, and antibacterial activity of N-linked conjugates of eremomycin with adamantanecarboxylic acids

  • V. V. Kovalev
  • L. M. Alimbarova
  • E. A. Shokova
  • G. S. Katrukha
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N1-linked conjugates of eremomycin with 1-adamantylacetic and p-(1-adamantyl)phenoxyacetic acids were synthesized for the first time. Their activity against herpes simplex virus 2 (HSV-2) was demonstrated (SI ∼ 10). At the same time, modification of the N-methylleucine fragment of eremomycin with adamantanecarboxylic acids led to some decrease in antibacterial activity.

Key words

semisynthetic glycopeptide antibiotics adamantylated eremomycin antibacterial and antiviral Activity 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • V. V. Kovalev
    • 1
  • L. M. Alimbarova
    • 2
  • E. A. Shokova
    • 1
  • G. S. Katrukha
    • 3
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia
  2. 2.Ivanovsky Institute of VirologyRussian Academy of Medical Sciences (RAMS)MoscowRussia
  3. 3.Gauze Institute of New AntibioticsRAMSMoscowRussia

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