Advertisement

Pharmaceutical Chemistry Journal

, Volume 43, Issue 7, pp 422–424 | Cite as

Application of low-angle laser scattering to the quality control of pharmaceutical powders and suspensions. 2. Barium sulfate

  • A. S. Ul’yantsev
  • E. V. Uspenskaya
  • N. S. Sorokina
  • T. V. Pleteneva
  • A. V. Syroeshkin
Studies of the Structures of Chemical Compounds and Analysis and Production Control Methods
  • 53 Downloads

Low-angle light scattering was used for dispersion analysis of samples of barium sulfate substance for radiography obtained from various manufacturers. Particles with sizes of greater than 10 μm were detected, which is not in compliance with normative specifications. Results obtained using barium sulfate substance as an example allow the low-angle laser light scattering method to be recommended for the rapid control of particle size in the disperse phases of medicinal suspensions and powders.

Key words

Powders and suspensions barium sulfate dispersion analysis low-angle laser light scattering 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    European Pharmacopeia, EP 5.2, 1053 (2005).Google Scholar
  2. 2.
    United States Pharmacopeia, USP 29, 197 – 198 (2005).Google Scholar
  3. 3.
    Japanese Pharmacopeia, JP XV, 334 – 335 (2007).Google Scholar
  4. 4.
    B. M. Nagaraja, H. Abimanyu, and K. D. Jung, J. Colloid Interface Sci., 316(2), 645 – 651 (2007).CrossRefPubMedGoogle Scholar
  5. 5.
    A. V. Syroeshkin, P. I. Popov, A. V. Balyshev, et al., Khim.-Farm. Zh., 38(11), 43 – 48 (2004).Google Scholar
  6. 6.
    B. L. Moldaver, and É. A. Kudryakova, Medtekhnika i Medizdeliya, 2(8), 14 – 17 (2002).Google Scholar
  7. 7.
    Kh. Otto, Vestn. Rentgenol. Radiol., 4, 15 (1991).PubMedGoogle Scholar
  8. 8.
    I. P. Korolyuk, V. M. Shinkin, L. I. Kuz’mina, et al., Vestn. Rentgenol. Radiol., 4(15), 34 – 38 (1984).Google Scholar
  9. 9.
    V. Lotz and S. Libenoff, Fortschrit. Geb. Rontgenstrahl. Nuklearmed., 131(2), 157 – 165 (1979).CrossRefGoogle Scholar
  10. 10.
    O. Ekberg, M. Bulow, and S. Eknam, Acta Radiol., 50(2), 131 – 138 (2008).CrossRefGoogle Scholar
  11. 11.
    T. V. Pleteneva, P. I. Popov, A. V. Syroeshkin, et al., Vedom. Nauchn. Centra Éxp. Sred. Med. Primen., 4, 104 – 107 (2007).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • A. S. Ul’yantsev
    • 1
  • E. V. Uspenskaya
    • 1
  • N. S. Sorokina
    • 1
  • T. V. Pleteneva
    • 1
  • A. V. Syroeshkin
    • 1
  1. 1.Russian University of the Friendship of the PeoplesMoscowRussia

Personalised recommendations