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Physicochemical parameters of perfluorocarbon emulsions with different osmolarities

  • I. N. Kuznetsova
  • V. S. Yurchenko
  • G. A. Kochetkova
Drug Synthesis and Production Technology

The physicochemical properties of emulsions based on perfluorocarbons (PFC) and phospholipids (PL) with osmolarities from ~80 to ~230 mOsm were studied in conditions of normal storage at +4°C and in “accelerated aging” storage at +37°C. Heat sterilization of emulsions with osmolarities of ~80 mOsm had no effect on particle size or structure. The pH and structure of these media remained unchanged for 12 months of normal storage. Increases in the osmolarity to ~230 mOsm had no effect on the stability of the emulsions: particle size and structure and pH and viscosity remained unaltered for 30 – 40 days of “accelerated aging” or for a year in normal (+4°C) conditions.

Key words

Emulsion perfluorocarbons phospholipids osmolarity stability (+4°C) 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • I. N. Kuznetsova
    • 1
  • V. S. Yurchenko
    • 1
  • G. A. Kochetkova
    • 1
  1. 1.State Russian Science Research Institute of Hematology and TransfusionsSt. PetersburgRussia

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