Effect of antiorthostatic hypokinesia on acetaminophen pharmacokinetics and its distribution in saliva of healthy volunteers
The pharmacokinetics of acetaminophen in a group of healthy volunteers has been studied after a single peroral administration at a dose of 625 mg under normal and antiorthostatic hypokinesia (head-down bed rest) conditions. A highly significant correlation has been established between the concentrations of acetaminophen in the blood plasma and saliva of volunteers and also between the pharmacokinetic parameters calculated from the dynamics of drug distribution in plasma and saliva. Atendency toward increased concentration of acetaminophen in saliva compared to blood plasma of volunteers; decreased time of attaining the maximum drug concentration, relative bioavailability, time of half-elimination, and mean retention time in the organism; and increased general clearance has been observed.
Key wordsacetaminophen pharmacokinetics plasma saliva orthostatic hypokinesia
- 1.L. Putcha, N. M. Cintron, J. M. Vanderploeg, et al., World Conference on Clin. Pharmacol. and Therapeutics (Abstract), Stockholm (1986).Google Scholar
- 3.A. A. Agafonov and V. K. Piotrovskii, Khim.-farm. Zh., 25, No. 10, 16 – 19 (1991).Google Scholar
- 4.I. B. Bondareva, V. B. Gerasimov, A. P. Drozhzhin, et al., Qualitative Investigations of Drug Bioequivalency [in Russian], Methodical Instructions, Moscow (2004).Google Scholar