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Synthesis and antimicrobial activity of quaternary salts of the alkaloid glaucine

  • A. Zh. Turmukhambetov
  • G. K. Mukusheva
  • R. B. Seidakhmetova
  • E. E. Shults
  • M. M. Shakirov
  • I. Yu. Bagryanskaya
  • Yu. V. Gatilov
  • S. M. Adekenov
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Quaternary salts of the alkaloid glaucine with alkyl iodides have been obtained. The crystal and molecular structure of the methyl iodide salt was studied by x-ray structure analysis. The synthesized compounds were tested for antimicrobial activity with respect to both Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli) bacteria.

Key words

aporphine alkaloids glaucine ethyl iodide and methyl iodide of tetramethoxyaporphine x-ray structure analysis antimicrobial activity 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • A. Zh. Turmukhambetov
    • 1
  • G. K. Mukusheva
    • 1
  • R. B. Seidakhmetova
    • 1
  • E. E. Shults
    • 2
  • M. M. Shakirov
    • 2
  • I. Yu. Bagryanskaya
    • 2
  • Yu. V. Gatilov
    • 2
  • S. M. Adekenov
    • 1
  1. 1.Phytochemistry Research and Production CenterKaragandaKazakhstan
  2. 2.Vorozhtsov Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussia

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