Methods for the synthesis of new heterosystems including condensed pyrano[4′,3′:4,5]pyrido[2,3-b]-thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines, thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinolines, and cyclopenta[4′,3′:4,5]pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino)[3,2-a]pyrimidines are developed. The synthesis is carried out on the basis of 1-amino-2-ethoxycarbonylpyrano[4,3-d]thieno[2,3-b]pyridines and -thieno[2,3-b]isoquinolines. Antitumor and anticonvulsant properties of the synthesized products have been evaluated. Compounds possessing low toxicity and moderate biological activity are found.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 3, pp. 17–21, March, 2009.
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Paronikyan, E.G., Akopyan, S.F., Noravyan, A.S. et al. Synthesis and biological activity of condensed derivatives of thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines. Pharm Chem J 43, 139–143 (2009). https://doi.org/10.1007/s11094-009-0253-8
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DOI: https://doi.org/10.1007/s11094-009-0253-8
Key words
- pyrano[4′,3′:4,5]pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidine
- thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinoline
- cyclopenta[4′,3′:4,5]-pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino)[3,2-a]pyrimidine
- 1-amino-2-ethoxycarbonylpyrano[4,3-d]-thieno[2,3-b]pyridines and -thieno[2,3-b]isoquinoline