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Pharmaceutical Chemistry Journal

, Volume 43, Issue 3, pp 139–143 | Cite as

Synthesis and biological activity of condensed derivatives of thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines

  • E. G. Paronikyan
  • Sh. F. Akopyan
  • A. S. Noravyan
  • G. A. Panosyan
  • G. M. Stepanyan
  • B. T. Garibdzhanyan
  • I. A. Dzhagatspanyan
  • I. M. Nazaryan
  • A. G. Akopyan
Article

Methods for the synthesis of new heterosystems including condensed pyrano[4′,3′:4,5]pyrido[2,3-b]-thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines, thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinolines, and cyclopenta[4′,3′:4,5]pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino)[3,2-a]pyrimidines are developed. The synthesis is carried out on the basis of 1-amino-2-ethoxycarbonylpyrano[4,3-d]thieno[2,3-b]pyridines and -thieno[2,3-b]isoquinolines. Antitumor and anticonvulsant properties of the synthesized products have been evaluated. Compounds possessing low toxicity and moderate biological activity are found.

Key words

pyrano[4′,3′:4,5]pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidine thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinoline cyclopenta[4′,3′:4,5]-pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino)[3,2-a]pyrimidine 1-amino-2-ethoxycarbonylpyrano[4,3-d]-thieno[2,3-b]pyridines and -thieno[2,3-b]isoquinoline 

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References

  1. 1.
    T. H. Brown and R. J. Ife, Eur. Pat. No. 404,356 (1990); Chem. Abstr., 115, 8821g (1991).Google Scholar
  2. 2.
    M. J. Munchhof, PCT Int. 9,924,440 (1999); Chem. Abstr., 131, 5266z (1999).Google Scholar
  3. 3.
    E. G. Paronikyan, G. V. Mirzoyan, A. S. Noravyan, et al., Khim.-farm. Zh., 31(10), 34–36 (1997).Google Scholar
  4. 4.
    K. Gewald, M. Hentschel, and U. Illigen, J. Prakt. Chem., 316, 1030 (1974).CrossRefGoogle Scholar
  5. 5.
    G. N. Pershin, Metods in Experimental Chemotherapy [in Russian], Medgiz, Moscow (1971).Google Scholar
  6. 6.
    Z. P. Sof´in, A. B. Syrkin, A. Goldin, and A. Klyain, eds., Experimental Evaluation of Antitumor Preparations in the USSR and USA [in Russian], Meditsina, Moscow (1979).Google Scholar
  7. 7.
    H. G. Vogel and W. H. Vogel, eds., Drug Discovery and Evaluation, Pharmacological Assays, Springer, Berlin and New York (1997), pp. 246–350.Google Scholar
  8. 8.
    A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, et al., Khim.-farm. Zh., 32(9), 15–19 (1998).Google Scholar
  9. 9.
    I. A. Dzhagatspanyan and A. B. Asryan, Eksp. Klin. Farmakol., No. 1, 5–8 (1994).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • E. G. Paronikyan
    • 1
    • 2
  • Sh. F. Akopyan
    • 1
    • 2
  • A. S. Noravyan
    • 1
    • 2
  • G. A. Panosyan
    • 1
    • 2
  • G. M. Stepanyan
    • 1
    • 2
  • B. T. Garibdzhanyan
    • 1
    • 2
  • I. A. Dzhagatspanyan
    • 1
    • 2
  • I. M. Nazaryan
    • 1
    • 2
  • A. G. Akopyan
    • 1
    • 2
  1. 1.Mndzhoyan Institute of Fine Organic ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia
  2. 2.Molecular Structure Research CenterNational Academy of Sciences of ArmeniaYerevanArmenia

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