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Pharmaceutical Chemistry Journal

, Volume 42, Issue 12, pp 708–711 | Cite as

Synthesis and characterization of coordination compounds of silver and tryptophan

  • G. M. Bobiev
  • T. Sufiev
  • A. N. Shakhmatov
  • Kh. Sh. Abdulov
Drug Synthesis Methods and Manufacturing Technology

It is shown using the isomolar series method that the synthesis of coordination compounds of silver and tryptophan both by direct interaction of AgNO3 with tryptophan and via the formation of an intermediate silver hydroxide yields target compounds with silver:tryptophan molar ratios 1:2, 1:1, and 2:1. It is established by pH-titration that synthesis of coordination compounds of silver and tryptophan via the intermediate silver oxide forms four complexes with logarithms of stability constants log \(\log {\upbeta} _{{{\left[ {{\text{Ag}}{\left( {{\text{HL}}^{ \pm } } \right)}} \right]}^{ + } }} = \pm 5.824\), \(\log {\upbeta} _{{{\left[ {{\text{Ag}}{\left( {{\text{HL}}^{ \pm } } \right)}^{2} } \right]}^{ + } }} = - 3.523\), \(\log {\upbeta} _{{{\left[ {{\text{AgL}}} \right]}^{0} }} = 4.103\), \(\log {\upbeta} _{{{\left[ {{\text{AgL}}_{{\text{2}}} } \right]}^{ - } }} = 6.805\), and \(\log {\upbeta} _{{{\left[ {{\text{AgL}}{\left( {{\text{HL}}} \right)}} \right]}}} = 5.771\).

Keywords

Stability Constant Coordination Compound Coordination Complex Acid Dissociation Constant Potassium Chromate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • G. M. Bobiev
    • 1
  • T. Sufiev
    • 1
  • A. N. Shakhmatov
    • 2
  • Kh. Sh. Abdulov
    • 2
  1. 1.State Suervision Center for Pharmaceutical and Medical ActivityDushanbeTajikistan
  2. 2.Zand Joint-Stock CompanyDushanbeTajikistan

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