Advertisement

Pharmaceutical Chemistry Journal

, Volume 42, Issue 6, pp 326–328 | Cite as

Synthesis and antimicrobial activity of sulfanilamide-containing copper (II) naphthalidenethiosemicarbazidates

  • A. P. Gulya
  • V. I. Prisakar
  • V. I. Tsapkov
  • S. A. Buracheva
  • S. N. Spynu
  • N. P. Bezhenar
The Search for New Therapeutic Substances

Abstract

Aseries of copper (II) streptocide-, sulfacyl-, norsulfazole-, ethazole-, and sulfadimezine-containing naphthalidenethiosemicarbazidates and napthalidene-4-phenylthiosemicarbazidates with high levels of antimicrobial activity were synthesized. Elemental analysis, magnetochemical, IR spectroscopic, and thermogravimetric data were used to confirm the compositions and structures of the resulting complexes. The effects of the nature of the central atom and the influences of the sulfanilamide and phenyl radicals in the azomethine thiosemicarbazone fragment on the antimicrobial activity of the compounds against 10 strains of Gram positive and Gram negative microorganisms were studied. The most active of the compounds synthesized were the copper norsulfazole-, ethazole-, and sulfadimezine-containing naphthalidenethiosemicarbazidates.

Keywords

Antimicrobial Activity Thiosemicarbazones Sulfanilamide Effective Magnetic Moment Complex VIII 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    V. I. Prisakar', V. I. Tsapkov, S. A. Buracheva, et al., Khim.-Farm. Zh., 39, No. 5, 93–95 (2005).Google Scholar
  2. 2.
    A. B. Tomchin, V. S. Velezheva, and E. B. Shustov, Khim.-Farm. Zh., 32, No. 2, 7–10 (1998).Google Scholar
  3. 3.
    O. V. Fedorova, G. G. Mordovskii, G. L. Rusinov, et al., Khim.-Farm. Zh., 32, No. 2, 11–12 (1998).Google Scholar
  4. 4.
    K. N. Zelenin, O. B. Kuznetsova, A. G. Saminskaya, et al., Khim.-Farm. Zh., 28, No. 2, 34–37 (1994).Google Scholar
  5. 5.
    V. V. Lukov, N. A. Abramova, V. A. Kogan, et al., Zh. Neorg. Khimii, 33, No. 2, 391–396 (1988).Google Scholar
  6. 6.
    N. M. Samus', V. I. Prisakar', V. I. Tsapkov, et al., Khim.-Farm. Zh., 38, No. 7, 27–29 (2004).Google Scholar
  7. 7.
    N. V. Gérbéléu, Author's Abstract of Doctoral Thesis in Chemical Sciences, Moscow (1973).Google Scholar
  8. 8.
    G. N. Pershin, Methods in Experimental Chemotherapy [in Russian], Meditsina, Moscow (1971), pp. 357–359.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • A. P. Gulya
    • 1
  • V. I. Prisakar
    • 2
  • V. I. Tsapkov
    • 1
  • S. A. Buracheva
    • 2
  • S. N. Spynu
    • 1
  • N. P. Bezhenar
    • 1
  1. 1.Moldova State UniversityKishinevMoldova
  2. 2.N. Testemitsan State University of Medicine and PharmacyKishinevMoldova

Personalised recommendations