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Pharmaceutical Chemistry Journal

, Volume 42, Issue 4, pp 169–174 | Cite as

Synthesis and tuberculostatic activity of fluorine-containing derivatives of quinolone, quinazolinone, and benzothiazinone

  • É. V. Nosova
  • G. N. Liponova
  • M. A. Kravchenko
  • A. A. Laeva
  • V. N. Charushin
Article

Abstract

Methods for the synthesis of fluorine-containing derivatives of quinolones, quinazolinones, and benzothiazinones based on the interaction of polyfluorobenzoic acid chloranhydrides with N,N-N,C-, and N,S-dinucleophiles are described. Use of (tetrafluorobenzoyl)isothiocyanate as the fluorine-containing block provides extensive opportunities for the synthesis of 2-substituted benzothiazinones. Some of the fluorine-containing azaheterocyclic compounds synthesized here had moderate and high activity against Mycobacterium tuberculosis H37Rv.

Keywords

Atomic Formula Quinazolinones Fluorobenzoyl Tuberculostatic Activity Tetrafluorobenzoyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • É. V. Nosova
    • 1
  • G. N. Liponova
    • 1
  • M. A. Kravchenko
    • 3
  • A. A. Laeva
    • 1
  • V. N. Charushin
    • 2
  1. 1.Urals State Technical UniversityEkaterinburgRussia
  2. 2.I. Ya. Postovskii Institute of Organic Synthesis, Urals BranchRussian Academy of SciencesEkaterinburgRussia
  3. 3.State Science Research Institute “Ftiziopul’monologiya”Ministry of Health of the Russian FederationEkaterinburgRussia

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