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Pharmaceutical Chemistry Journal

, Volume 41, Issue 12, pp 643–645 | Cite as

Synthesis and antibacterial activity of N,N′-diaryl-2-aryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides

  • V. L. Gein
  • E. V. Levandovskaya
  • N. V. Nosova
  • N. V. Antonova
  • E. V. Voronina
  • M. I. Vakhrin
  • A. P. Krivenko
Article

Abstract

A series of N,N′-diaryl-2-aryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides have been synthesized by the reaction of N-arylamides of acetoacetic acid with aromatic aldehydes in the presence of piperidine. The structures of the products were determined by IR, PMR, and mass spectroscopy. Data on the antimicrobial activity of the synthesized compounds are presented.

Keywords

Antimicrobial Activity Piperidine Aromatic Aldehyde Unsaturated Ketone Piperidone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    V. L. Gein, N. V. Gein, E. V. Voronina, and A. P. Krivenko, Khim.-Farm. Zh., 36(3), 23–26 (2002).Google Scholar
  2. 2.
    V. L. Gein, A. A. Zorina, N. V. Gein, et al., Khim.-Farm. Zh., 39(4), 21–23 (2005).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • V. L. Gein
    • 1
  • E. V. Levandovskaya
    • 1
  • N. V. Nosova
    • 1
  • N. V. Antonova
    • 1
  • E. V. Voronina
    • 1
  • M. I. Vakhrin
    • 1
  • A. P. Krivenko
    • 2
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Saratov State UniversitySaratovRussia

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