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Synthesis and conversions of polyhedral compounds: 28. Synthesis and psychotropic activity of some 1,3-diazaadamantane derivatives

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Abstract

The anticonvulsant and tranquilizer properties of some new derivatives of 1,3-diazaadamantane have been investigated. It is established that some of the synthesized compounds prevent corazole-induced convulsions in mice in a dose range of 18–75 mg-kg. The study of the influence of these compounds on the behavior of rats under open-field test conditions revealed a pronounced tranquilizer action.

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Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan, 375014, Armenia

    G. L. Arutyunyan, I. A. Dzhagatspanyan, I. M. Nazaryan, A. G. Akopyan & A. D. Arutyunyan

Authors
  1. G. L. Arutyunyan
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  2. I. A. Dzhagatspanyan
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  3. I. M. Nazaryan
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  4. A. G. Akopyan
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  5. A. D. Arutyunyan
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 11, pp. 25–26, November, 2007.

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Arutyunyan, G.L., Dzhagatspanyan, I.A., Nazaryan, I.M. et al. Synthesis and conversions of polyhedral compounds: 28. Synthesis and psychotropic activity of some 1,3-diazaadamantane derivatives. Pharm Chem J 41, 591–593 (2007). https://doi.org/10.1007/s11094-008-0025-x

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  • DOI: https://doi.org/10.1007/s11094-008-0025-x

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