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Pharmaceutical Chemistry Journal

, Volume 41, Issue 11, pp 591–593 | Cite as

Synthesis and conversions of polyhedral compounds: 28. Synthesis and psychotropic activity of some 1,3-diazaadamantane derivatives

  • G. L. Arutyunyan
  • I. A. Dzhagatspanyan
  • I. M. Nazaryan
  • A. G. Akopyan
  • A. D. Arutyunyan
Article

Abstract

The anticonvulsant and tranquilizer properties of some new derivatives of 1,3-diazaadamantane have been investigated. It is established that some of the synthesized compounds prevent corazole-induced convulsions in mice in a dose range of 18–75 mg-kg. The study of the influence of these compounds on the behavior of rats under open-field test conditions revealed a pronounced tranquilizer action.

Keywords

Memantine Adamantane Levulinic Acid Urotropine Adamantane Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    S. K. Sonkusare, C. L. Kaul, and P. Ramarao, Pharmacol Res., 51(1), 1–17 (2005).PubMedGoogle Scholar
  2. 2.
    V. N. Shtok and N. V. Fedorova, Psikhiatr. Psikhofarmakoter., 2(3) (2000).Google Scholar
  3. 3.
    V. E. Gmiro and S. E. Serdyuk, Neirofarmakologiya, No. 6 (2000).Google Scholar
  4. 4.
    K. Gerzon, D. J. Tobias, R. E. Holmes, et al., J. Med. Chem, 10, 603–606 (1967).PubMedCrossRefGoogle Scholar
  5. 5.
    Ts. E. Agadzhanyan, G. L. Arutyunyan, G. Kh. Grigoryan, et al., USSR Inventor’s Certificate, No. 1162195 (1984).Google Scholar
  6. 6.
    A. I. Kuznetsov, E. B. Basargin, M. Kh. Ba, et al., Khim. Geterotsikl. Soedin., No. 5, 647–653 (1989).Google Scholar
  7. 7.
    Drug Discovery and Evaluation: Pharmacological Assays, H. G. Vogel and W. H. Vogel (eds.), Springer, Berlin (1997), pp. 246–350.Google Scholar
  8. 8.
    A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, et al., Khim.-Farm. Zh., 32(9), 15–19 (1998).Google Scholar
  9. 9.
    I. A. Dzhagatspanyan and A. B. Asryan, Éksp. Klin. Farmakol., No. 1, 5–8 (1994).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • G. L. Arutyunyan
    • 1
  • I. A. Dzhagatspanyan
    • 1
  • I. M. Nazaryan
    • 1
  • A. G. Akopyan
    • 1
  • A. D. Arutyunyan
    • 1
  1. 1.Mndzhoyan Institute of Fine Organic ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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