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Search for the optimal conditions for the distillation of the antibacterial agent glyciphon

  • Drug Synthesis Methods and Manufacturing Technology
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Pharmaceutical Chemistry Journal Aims and scope

Abstract

Preparation of the high-boiling-point organophosphate antiblastoma agent glyciphon at maximal yield and purity was addressed at the experimental production stage by studying its vacuum distillation by mathematical modeling. The optimum conditions for performing this final stage of the technical process allowed the number of distillations to be decreased and the yield of pharmacological purity product to be increased by an average of 20%.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan’ Scientific Center, Russian Academy of Sciences, Russia

    I. V. Berdnik, A. A. Muslinkin & I. M. Magdeev

Authors
  1. I. V. Berdnik
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  2. A. A. Muslinkin
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  3. I. M. Magdeev
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 6, pp. 35–38, June, 2007.

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Berdnik, I.V., Muslinkin, A.A. & Magdeev, I.M. Search for the optimal conditions for the distillation of the antibacterial agent glyciphon. Pharm Chem J 41, 323–326 (2007). https://doi.org/10.1007/s11094-007-0073-7

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  • DOI: https://doi.org/10.1007/s11094-007-0073-7

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