Search for the optimal conditions for the distillation of the antibacterial agent glyciphon
- 29 Downloads
Preparation of the high-boiling-point organophosphate antiblastoma agent glyciphon at maximal yield and purity was addressed at the experimental production stage by studying its vacuum distillation by mathematical modeling. The optimum conditions for performing this final stage of the technical process allowed the number of distillations to be decreased and the yield of pharmacological purity product to be increased by an average of 20%.
KeywordsVacuum Distillation Distillation Process Glycidol Azeotropic Mixture Trigger Time
Unable to display preview. Download preview PDF.
- 1.A. A. Muslinkin, Ya. A. Levin, I. P. Gozman, et al., Khim.-Farm. Zh., 34(5), 41–43 (2000).Google Scholar
- 2.I. V. Berdnik, T. V. Timoshina, A. A. Muslinkin, et al., Khim.-Farm. Zh., 36(3), 43–45 (2002).Google Scholar
- 3.A. Yu. Zakgeim, Introduction to the Modeling of Chemical Technological Processes [in Russian], Khimiya, Moscow (1982), pp. 26–46.Google Scholar
- 4.A. G. Bondar’ and G. A. Statyukha, Planning of Experiments in Chemical Technology [in Russian], Vysshaya Shkola, Kiev (1976), pp. 16–128.Google Scholar
- 5.G. G. Devyatykh and Yu. E. Elliev, Preparation of High-Purity Substances [in Russian], Vysshaya Shkola, Moscow (1974), pp. 29–80.Google Scholar
- 6.I. M. Bronstein and K. A. Semendyaev, Handbook of Mathematics for Engineers and Advanced Students [in Russian], “Teubner,” Leipzig (1979); Nauka, Moscow (1979), pp. 98–101.Google Scholar