Pharmaceutical Chemistry Journal

, Volume 41, Issue 6, pp 323–326 | Cite as

Search for the optimal conditions for the distillation of the antibacterial agent glyciphon

  • I. V. Berdnik
  • A. A. Muslinkin
  • I. M. Magdeev
Drug Synthesis Methods and Manufacturing Technology


Preparation of the high-boiling-point organophosphate antiblastoma agent glyciphon at maximal yield and purity was addressed at the experimental production stage by studying its vacuum distillation by mathematical modeling. The optimum conditions for performing this final stage of the technical process allowed the number of distillations to be decreased and the yield of pharmacological purity product to be increased by an average of 20%.


Vacuum Distillation Distillation Process Glycidol Azeotropic Mixture Trigger Time 
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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • I. V. Berdnik
    • 1
  • A. A. Muslinkin
    • 1
  • I. M. Magdeev
    • 1
  1. 1.A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan’ Scientific CenterRussian Academy of SciencesRussia

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