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Pharmaceutical Chemistry Journal

, Volume 41, Issue 5, pp 256–263 | Cite as

Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrrolin-2-ones

  • V. L. Gein
  • V. V. Yushkov
  • N. N. Kasimova
  • E. V. Voronina
  • N. S. Rakshina
  • M. Yu. Vasil’eva
Article

Abstract

A series of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrroline-2-ones was synthesized via the reactions of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and 2-(4-morpholino)-1-ethylamine or 3-(4-morpholino)-1-propylamine. All compounds possess weak antibacterial properties. The antiamnesic, analgesic, and antiphlogistic activity and acute toxicity of several compounds were studied. It was established that one compound produced a significant antiamnesic effect and two compounds exhibited pronounced analgesic activity.

Keywords

Aromatic Aldehyde Piracetam Analgin Ethacridine Lactate Perm State Pharmaceutical Academy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • V. L. Gein
    • 1
  • V. V. Yushkov
    • 1
  • N. N. Kasimova
    • 1
  • E. V. Voronina
    • 1
  • N. S. Rakshina
    • 1
  • M. Yu. Vasil’eva
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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