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HPLC determination of the new cardiotropic drug protecor in blood serum of animals

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Abstract

An HPLC-based method with ultraviolet detection has been developed for determining the new cardiotropic drug protecor in the blood and applied to monitoring of the drug pharmacokinetics after intravenous administration in experimental animals (rabbits and beagle dogs). Ahigh initial concentration of protecor in the blood plasma, followed by rapid drug elimination has been observed after administration in a single dose to beagles (25 mg/kg) and rabbits (100 mg/kg). The drug half-elimination time was 0.47 and 0.32 h for dogs and rabbits, respectively.

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References

  1. L. N. Sernov and N. M. Mitrokhin, Bulletin of the All-Russia Scientific Center for Safety Testing of Biologically Active Substances [in Russian], Moscow (2000), pp. 32–43.

  2. L. N. Sernov, L. D. Smirnov, and O. G. Kesarev, Abstracts of Papers. The 5th All-Russia Congress “Humans and Drugs” [in Russian], Moscow (1998), p. 619.

  3. I. I. Miroshnichenko, I. I. Tyulyaev, and A. P. Zuev, Bioaccessibility of Drugs [in Russiaqn], Gramotei, Moscow (2003).

    Google Scholar 

  4. V. N. Solov’ev, A. A. Firsov, and V. A. Filov, Pharmacokinetics [in Russian], Meditsina, Moscow (1980).

    Google Scholar 

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Authors and Affiliations

  1. All-Russia Scientific Center for Safety Testing of Biologically Active Substances, Ministry of Public Health of the Russian Federation, Staraya Kupavna, Moscow oblast, Russia

    S. N. Ptitsina, V. I. Bobrov, L. N. Serov, M. M. Borisov, I. Kh. Ivanova & I. I. Miroshnichenko

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  1. S. N. Ptitsina
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  2. V. I. Bobrov
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  3. L. N. Serov
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  4. M. M. Borisov
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  5. I. Kh. Ivanova
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  6. I. I. Miroshnichenko
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 12, pp. 44–46, December, 2006.

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Ptitsina, S.N., Bobrov, V.I., Serov, L.N. et al. HPLC determination of the new cardiotropic drug protecor in blood serum of animals. Pharm Chem J 40, 683–685 (2006). https://doi.org/10.1007/s11094-006-0219-z

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  • DOI: https://doi.org/10.1007/s11094-006-0219-z

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