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Pharmaceutical Chemistry Journal

, Volume 40, Issue 11, pp 627–632 | Cite as

Pharmacologically active substances from Ambrosia artemisiifolia. Part 2

  • A. Yu. Parkhomenko
  • E. T. Oganesyan
  • O. A. Andreeva
  • E. G. Dorkina
  • E. O. Paukova
  • Z. S. Agadzhanyan
Article

Abstract

A new scheme of the isolation of all fractions of polyphenolic compounds from wormwood-leaved ambrosia (Ambrosia artemisiifolia L.) collected in the budding period is proposed. The main components in the total extract are phenolcarboxylic acids (ferulic, isoferulic, caffeic, chlorogenic acids and caffeic acid glycoside) coumarins (scopoletin, scopolin, esculetin, esculin, umbelliferone, skimmin), and flavonoids (jaceidin, quercetin, isorhamnetin, isorhamnetin-3-rutinoside, quercimeritrin, isoquercitrin, and glycosides of xanthomicrol and 4′,5-dihydroxy-3,6,7,8-tetramethoxyflavone). Polymethoxylated flavonoids have been identified in ambrosia and characterized for the first time, including jaceidin (5,7,4′-trihydroxi-3,6,3′-trimethoxyflavone), xanthomicrol (4′, 5-dihydroxy-6,7,8-trimethoxyflavone), 4′,5-dihydroxy-3,6,7,8-tetramethoxyflavone, and their glycosides. The results of biological investigations of the obtained polyphenolic fractions showed their pronounced hepatoprotective properties (exceeding those of the well-known drug karsil) and hypolipemic activity (comparable with that of lipanor).

Keywords

Coumarin Sesquiterpene Lactone Scopoletin Esculetin Ambrosia Artemisiifolia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • A. Yu. Parkhomenko
    • 1
  • E. T. Oganesyan
    • 1
  • O. A. Andreeva
    • 1
  • E. G. Dorkina
    • 1
  • E. O. Paukova
    • 1
  • Z. S. Agadzhanyan
    • 1
  1. 1.Pyatigorsk State Pharmaceutical AcademyPyatigorskRussia

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