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Pharmaceutical Chemistry Journal

, Volume 40, Issue 10, pp 540–543 | Cite as

Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells

  • E. N. Kudinova
  • N. F. Salakhutdinov
  • V. V. Fomenko
  • N. N. Vol’skii
  • O. M. Perminova
  • O. N. Khoshchenko
  • Y. Ch. Shwarts
  • M. I. Dushkin
Article
  • 53 Downloads

Abstract

The synthesis of a water-soluble compound belonging to the group of terpenoids-disodium salt of a resorcinol derivative of caryophyllene-is described. The biological properties of the new compound have been studied in mice in comparison to some native terpenoids and atorvastatin. The synthesized terpenoid (5 mg/mouse) decreases the rate of cholesterol biosynthesis in murine liver. Similar effects were observed for atorvastatin (0.2 mg/mouse) and the native terpenoids (8.5 mg/mouse), except for perillic alcohol (which produced a stimulating action). In addition, the obtained resorcinol derivative of caryophyllene inhibits mitogen-stimulated murine splenic cell proliferation in vitro in a dose-dependent manner. The drug efficacy in this reaction is comparable with that of perillic alcohol and α-terpineol, while being less pronounced than the effect of dipentene and atorvastatin.

Keywords

Atorvastatin Terpenoid Disodium Salt Cholesterol Biosynthesis Dipentene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • E. N. Kudinova
    • 1
  • N. F. Salakhutdinov
    • 2
  • V. V. Fomenko
    • 2
  • N. N. Vol’skii
    • 3
  • O. M. Perminova
    • 3
  • O. N. Khoshchenko
    • 1
  • Y. Ch. Shwarts
    • 1
  • M. I. Dushkin
    • 1
  1. 1.Institute of Internal Medicine, Siberian DivisionRussian Academy of Medical SciencesNovosibirskRussia
  2. 2.Vorozhtsov Institute of Organic Chemistry, Siberian DivisionRussian Academy of SciencesNovosibirskRussia
  3. 3.Institute of Clinical Immunology, Siberian DivisionRussian Academy of Medical SciencesNovosibirskRussia

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