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Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells

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Abstract

The synthesis of a water-soluble compound belonging to the group of terpenoids-disodium salt of a resorcinol derivative of caryophyllene-is described. The biological properties of the new compound have been studied in mice in comparison to some native terpenoids and atorvastatin. The synthesized terpenoid (5 mg/mouse) decreases the rate of cholesterol biosynthesis in murine liver. Similar effects were observed for atorvastatin (0.2 mg/mouse) and the native terpenoids (8.5 mg/mouse), except for perillic alcohol (which produced a stimulating action). In addition, the obtained resorcinol derivative of caryophyllene inhibits mitogen-stimulated murine splenic cell proliferation in vitro in a dose-dependent manner. The drug efficacy in this reaction is comparable with that of perillic alcohol and α-terpineol, while being less pronounced than the effect of dipentene and atorvastatin.

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Authors and Affiliations

  1. Institute of Internal Medicine, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russia

    E. N. Kudinova, O. N. Khoshchenko, Y. Ch. Shwarts & M. I. Dushkin

  2. Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia

    N. F. Salakhutdinov & V. V. Fomenko

  3. Institute of Clinical Immunology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russia

    N. N. Vol’skii & O. M. Perminova

Authors
  1. E. N. Kudinova
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  2. N. F. Salakhutdinov
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  3. V. V. Fomenko
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  4. N. N. Vol’skii
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  5. O. M. Perminova
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  6. O. N. Khoshchenko
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  7. Y. Ch. Shwarts
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  8. M. I. Dushkin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 10, pp. 20–23, October, 2006.

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Kudinova, E.N., Salakhutdinov, N.F., Fomenko, V.V. et al. Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells. Pharm Chem J 40, 540–543 (2006). https://doi.org/10.1007/s11094-006-0188-2

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  • DOI: https://doi.org/10.1007/s11094-006-0188-2

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