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Stereoselective synthesis and neurotropic activity of phosphorylacetic acid derivatives

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Abstract

Stereoselective synthesis of an optically active menthyl ester of 2-chloroethoxy-4′-dimethylaminophenylphosphorylacetic acid (CAPAM) is described. The product structure was confirmed by elemental analyses and IR, NMR (1H, 13C, 31P), and mass spectroscopy measurements. When tested for neuropharmacological properties, CAPAM exhibited a neurotropic (deprivating) activity and myorelaxant action.

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Authors and Affiliations

  1. Kazan State Technological University, Kazan, Tatarstan, Russia

    R. I. Tarasova & O. V. Voskresenskaya

  2. Kazan State Medical University, Kazan, Tatarstan, Russia

    I. I. Semina, E. V. Shilovskaya, Sh. K. Latypov, A. A. Balandina & A. A. Bredikhin

  3. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, Russia

    R. M. Eliseenkova

Authors
  1. R. I. Tarasova
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  2. O. V. Voskresenskaya
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  3. R. M. Eliseenkova
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  4. I. I. Semina
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  5. E. V. Shilovskaya
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  6. Sh. K. Latypov
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  7. A. A. Balandina
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  8. A. A. Bredikhin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 9, pp. 9–11, September, 2006.

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Tarasova, R.I., Voskresenskaya, O.V., Eliseenkova, R.M. et al. Stereoselective synthesis and neurotropic activity of phosphorylacetic acid derivatives. Pharm Chem J 40, 469–472 (2006). https://doi.org/10.1007/s11094-006-0156-x

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  • DOI: https://doi.org/10.1007/s11094-006-0156-x

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