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Pharmaceutical Chemistry Journal

, Volume 40, Issue 7, pp 360–362 | Cite as

Synthesis and antiarrhythmic properties of N-acylamino derivatives of 1,6,7-substituted 1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs

  • É. A. Markaryan
  • Zh. S. Arustamyan
  • S. V. Avetisyan
  • R. É. Markaryan
  • K. Zh. Markaryan
  • T. O. Asatryan
  • A. V. Grigoryan
Article
  • 31 Downloads

Abstract

Aseries of new N-chloracetyl derivatives have been synthesized proceeding from 4-spirocyclopentane-substituted 1,2,3,4-tetrahydroisoquinolines, 1-phenyl-1-cyclopentylmethylamine, and chloroanhydrides of bromoacetic and α-bromopropionic acids. Reactions of these bromoamides with amines (piperidine, morpholine) yield the title N-acylamino derivatives. The antiarrhythmic properties of the synthesized compounds have been studied.

Keywords

Morpholine Potassium Iodide Antiarrhythmic Activity Aconitine Anhydrous Benzene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    A. L. Mndzhoyan and M. G. Tsinler., Arm. Khim. Zh., No. 1, 20–22 (1967).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • É. A. Markaryan
    • 1
  • Zh. S. Arustamyan
    • 1
  • S. V. Avetisyan
    • 1
  • R. É. Markaryan
    • 1
  • K. Zh. Markaryan
    • 1
  • T. O. Asatryan
    • 1
  • A. V. Grigoryan
    • 1
  1. 1.Mndzhoyan Institute of Fine Organic ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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