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Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-[2-(diethylamino)ethyl]-3-pyrrolin-2-ones

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Abstract

Aseries of 4,5-disubstituted 3-hydroxy-1-(2-diethylaminoethyl)-3-pyrrolin-2-ones were synthesized via reactions of methyl esters of acylpyruvic acid with a mixture of an aromatic aldehyde and 2-(diethylamino) ethylamine. The synthesized compounds were characterized with respect to antiinflammatory, antidepressant, and antibacterial properties and acute toxicity.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    V. L. Gein, V. V. Yushkov, N. N. Kasimova, N. S. Rakshina, M. V. Gubanova & É. V. Voronina

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  1. V. L. Gein
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  2. V. V. Yushkov
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  3. N. N. Kasimova
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  4. N. S. Rakshina
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  5. M. V. Gubanova
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  6. É. V. Voronina
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 5, pp. 14–16, May, 2006.

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Gein, V.L., Yushkov, V.V., Kasimova, N.N. et al. Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-[2-(diethylamino)ethyl]-3-pyrrolin-2-ones. Pharm Chem J 40, 248–250 (2006). https://doi.org/10.1007/s11094-006-0102-y

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  • DOI: https://doi.org/10.1007/s11094-006-0102-y

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