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Pharmaceutical Chemistry Journal

, Volume 40, Issue 5, pp 248–250 | Cite as

Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-[2-(diethylamino)ethyl]-3-pyrrolin-2-ones

  • V. L. Gein
  • V. V. Yushkov
  • N. N. Kasimova
  • N. S. Rakshina
  • M. V. Gubanova
  • É. V. Voronina
Article
  • 36 Downloads

Abstract

Aseries of 4,5-disubstituted 3-hydroxy-1-(2-diethylaminoethyl)-3-pyrrolin-2-ones were synthesized via reactions of methyl esters of acylpyruvic acid with a mixture of an aromatic aldehyde and 2-(diethylamino) ethylamine. The synthesized compounds were characterized with respect to antiinflammatory, antidepressant, and antibacterial properties and acute toxicity.

Keywords

Aromatic Aldehyde Ethylamine Diethylamino Carrageenan Injection Pyrrolin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. L. Gein
    • 1
  • V. V. Yushkov
    • 1
  • N. N. Kasimova
    • 1
  • N. S. Rakshina
    • 1
  • M. V. Gubanova
    • 1
  • É. V. Voronina
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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