Advertisement

Pharmaceutical Chemistry Journal

, Volume 39, Issue 8, pp 437–440 | Cite as

Optimization of the Composition and Technology of Diazoline Tablets

  • A. P. Zuev
  • S. V. Emshanova
  • N. B. Dragunova
  • N. P. Sadchikova
  • I. I. Tyulyaev
  • N. S. Novikova
Article
  • 26 Downloads

Abstract

Physicochemical properties (particle size and specific surface) of the parent substance of diazoline have been determined and the influence of these parameters on the drug dissolution characteristics have been studied. A technology of 0.1 g diazoline dragee containing PVP has been developed and the influence of this polymer on the quality of the ready-to-use preparation has been studied.

Keywords

Polymer Organic Chemistry Specific Surface Physicochemical Property Particle Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2003), Vol. 1, p. 279.Google Scholar
  2. 2.
    Pharmacopoeial Article FS 42-2925-98 with Modification No. 2. Diazoline 0.05 and 0.1 g dragee.Google Scholar
  3. 3.
    U. Z. Nazarov, I. F. Tishchenkova, and L. E. Kholodov, Khim.-Farm. Zh., 25(12), 11–13 (1991).Google Scholar
  4. 4.
    USSR State Pharmacopoeia, XI Ed. [in Russian], Meditsina, Moscow (1987), Vol. 2, pp. 154–160.Google Scholar
  5. 5.
    E. V. Kompantseva, M. V. Gavrilin, I. I. Monastyreva, et al., Khim.-Farm. Zh., 32(6), 46–48 (1998).Google Scholar
  6. 6.
    A. I. Tentsova and I. S. Azhgikhin, Medicinal Form and Therapeutic Efficacy of Drugs [in Russian], Meditsina, Moscow (1974), p. 335.Google Scholar
  7. 7.
    A. I. Tentsova and A. E. Dobrotvorskii, Farmatsiya, No. 2, 65 (1981).Google Scholar
  8. 8.
    A. M. Dubinskaya, L. D. Yakusheva, and E. G. Aver'eva, Khim.-Farm. Zh., 22(9), 1125–1129 (1988).Google Scholar
  9. 9.
    P. A. Kouzov, Principles of the Analysis of Dispersion Composition of Industrial Dusts and Powdered Materials [in Russian]. Khimiya, Leningrad (1987).Google Scholar
  10. 10.
    V. Buhler, Kollidon: Polyvinylpyrrolidone for Pharmaceutical Industry, BASF (1999).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • A. P. Zuev
    • 1
  • S. V. Emshanova
    • 1
  • N. B. Dragunova
    • 1
  • N. P. Sadchikova
    • 2
  • I. I. Tyulyaev
    • 1
  • N. S. Novikova
    • 1
  1. 1.“Akrikhin” Chemico-Pharmaceutical Joint-Stock CompanyStaraya Kupavna, Moscow OblastRussia
  2. 2.Sechenov Medical AcademyMoscowRussia

Personalised recommendations