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Pharmaceutical Chemistry Journal

, Volume 39, Issue 5, pp 245–247 | Cite as

Synthesis and Antimicrobial Activity of 5-(R1-benzyl)-2-(R2-benzylidenehydrazono)-3-(2-furylmethyl)Thiazolidin-4-ones

  • V. M. Tsyalkovsky
  • R. V. Kutsyk
  • V. S. Matiychuk
  • N. D. Obushak
  • T. I. Klyufinskaya
Article

Abstract

3-Aryl-2-bromopropanoic acid esters react with furfurylthiosemicarbazones of benzaldehyde and 4-chlorobenzaldehyde to form 5-(R1-benzyl)-2-(4-R-benzylidenehydrazono)-3-furfuryl-4-thiazolidinones (R = H, 4-Cl; R1 = 4-Me, 4-F, 4-Cl). The antimicrobial activity of the synthesized compounds was studied, and it was established that only the compounds with R1 = Me are active. The replacement of methyl group by halogen results in the loss of antimicrobial activity.

Keywords

Methyl Ester Organic Chemistry Antimicrobial Activity Benzaldehyde 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • V. M. Tsyalkovsky
    • 1
  • R. V. Kutsyk
    • 2
  • V. S. Matiychuk
    • 1
  • N. D. Obushak
    • 1
  • T. I. Klyufinskaya
    • 2
  1. 1.Lviv National UniversityLvivUkraine
  2. 2.Ivano-Frankivsk State Medical AcademyIvano-FrankivskUkraine

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