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Pharmaceutical Chemistry Journal

, Volume 39, Issue 4, pp 183–187 | Cite as

Synthesis and DNA-Binding Properties of 9-Formylacridine and 9-Formylanthracene Aminoacetylhydrazones

  • E. A. Lyakhova
  • S. A. Lyakhov
  • L. A. Litvinova
  • S. A. Andronati
  • M. N. Lebedyuk
  • V. P. Fedchuk
  • G. A. Khorokhorina
Article

Abstract

The dependence of the affinity of compounds to DNA on the structure of their fragments intercalating into the double helix was studied in a series of aminoacetylhydrazones of 9-formylacridine and 9-formylanthracene. The synthesized compounds were characterized by the intercalating properties and the ability to inhibit the polymerase chain reaction (PCR). The affinity to DNA was found to be higher for acridine derivatives (log Ka = 7.37 – 8.04) than for anthracene derivatives (log Ka = 5.37 – 6.12). At the same time, both acridines and anthracenes showed insignificant ability to inhibit PCR. Thus, no correlation between the affinity to DNA and the ability to inhibit DNA replication was observed for the compounds studied.

Keywords

Polymerase Chain Reaction Organic Chemistry Anthracene Acridine Double Helix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • E. A. Lyakhova
    • 1
  • S. A. Lyakhov
    • 1
  • L. A. Litvinova
    • 1
  • S. A. Andronati
    • 1
  • M. N. Lebedyuk
    • 2
  • V. P. Fedchuk
    • 2
  • G. A. Khorokhorina
    • 1
  1. 1.Bogatskii Institute of Physical ChemistryNational Academy of Sciences of UkraineOdessaUkraine
  2. 2.ITSW Research CenterOdessaUkraine

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