Correlation Between Ionization Constants and Antiinflammatory Activity of N-Substituted Anthranilic Acid Amides
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Eleven amides of N-substituted anthranilic acids have been synthesized and evaluated with respect to antiinflammatory activity. The ionization constants of the new compound were determined by means of potentiometric titration, and six correlation equations were constructed, which relate these values to the antiinflammatory action. Using these equations, the antiinflammatory effect of two other substances from the same series of compounds was predicted for the model of carrageenan-induced edema. The theoretical predictions were experimentally confirmed. The obtained correlation equations may be used for the prognosis of antiinflammatory activity in the series of N-substituted anthranilic acid amides.
KeywordsOrganic Chemistry Amide Theoretical Prediction Antiinflammatory Effect Antiinflammatory Activity
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