Synthesis and Tuberculostatic Activity of Some Substituted Amino Acid Methyl Esters with Sym-Tetrazine Moieties
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The products of nucleophilic substitution of methyl esters of seven amino acids for the 3,5-dimethylpyrazolyl moiety in 3,6-bis(3,5-dimethylpyrazol-l-yl)-5-tetrazine were obtained. One of these compounds exhibited tuberculocidal action at a concentration of 0.6 μg/ml. In contrast, two other compounds stimulated the growth of mycobacterium colonies.
KeywordsMethyl Ester Organic Chemistry Methyl Ester Acid Methyl Ester
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