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Pharmaceutical Chemistry Journal

, Volume 39, Issue 1, pp 8–10 | Cite as

Synthesis and Tuberculostatic Activity of Some Substituted Amino Acid Methyl Esters with Sym-Tetrazine Moieties

  • G. L. Rusinov
  • N. I. Latosh
  • R. I. Ishmetova
  • M. A. Kravchenko
  • I. N. Ganebnykh
  • V. A. Sokolov
  • O. N. Chupakhin
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Abstract

The products of nucleophilic substitution of methyl esters of seven amino acids for the 3,5-dimethylpyrazolyl moiety in 3,6-bis(3,5-dimethylpyrazol-l-yl)-5-tetrazine were obtained. One of these compounds exhibited tuberculocidal action at a concentration of 0.6 μg/ml. In contrast, two other compounds stimulated the growth of mycobacterium colonies.

Keywords

Methyl Ester Organic Chemistry Methyl Ester Acid Methyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • G. L. Rusinov
    • 1
  • N. I. Latosh
    • 1
  • R. I. Ishmetova
    • 1
  • M. A. Kravchenko
    • 2
  • I. N. Ganebnykh
    • 1
  • V. A. Sokolov
    • 2
  • O. N. Chupakhin
    • 1
  1. 1.Institute of Organic Synthesis, Ural DivisionRussian Academy of SciencesYekaterinburgRussia
  2. 2.Ural Research Institute of PhthisiopulmonologyYekaterinburgRussia

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