A New Start from Ground Zero?
- 265 Downloads
It is pointed out that one of the main reasons of lack of real conceptual progress in the field may lie in the fact that questions concerning the biogenesis of macromolecules have never been asked or addressed in a proper way. We should start again research on the origin of life starting from “ground zero” and focusing on the prebiotic synthesis of ordered sequences of proteins and nucleic acids.
KeywordsProtein biogenesis Catalytic peptides His-Ser Proteases-first Prebiotic amino acids
- Chiarabelli C, Vrijbloed JW, De Lucrezia D, Thomas RM, Stano P, Polticelli F, Ottone T, Papa E, Luisi PL (2006a) Investigation of de novo totally random biosequences, Part II: on the folding frequency in a totally random library of de novo proteins obtained by phage display. Chem Biodivers 3:840–859CrossRefPubMedGoogle Scholar
- Commeyras A, Boiteau L, Vandenabeele-Trambouze O, Selsis F (2005) Lectures in astrobiology, advances in astrobiology and biogeophysics. In: Gargaud M, Barbier B, Martin H, Reisse J (eds) Peptide emergence, evolution and selection on the primitive earth. Springer, Heidelberg, pp 547–569Google Scholar
- Gorlero M, Wieczorek R, Katarzina A, et al. (2009) Ser-His catalyses the information of peptides and PNAs. FEBS Letters 583:153–6Google Scholar
- Ikehara K (2005) Possible steps to the emergence of life: the [GADV]-protein world hypothesis. Chem Rec (New York, NY) 5:107–118Google Scholar