Origins of Life and Evolution of Biospheres

, Volume 37, Issue 4–5, pp 309–314 | Cite as

Question 1: Commentary Referring to the Statement “The Origin of Life can be Traced Back to the Origin of Kinetic Control” and the Question “Do You Agree with this Statement; and How Would You Envisage the Prebiotic Evolutionary Bridge Between Thermodynamic and Kinetic Control?” Stated in Section 1.1.



The paper summarizes thoughts induced by some of the programmatic questions Pier Luigi Luisi posed for discussion at the Erice workshop.


Thermodynamic versus kinetic reaction control Metabolic versus genetic autocatalytic cycles in prebiotic chemistry 


  1. Dyson F (1982) A model for the origin of life. J Mol Evol 18:344–350PubMedCrossRefGoogle Scholar
  2. Dyson F (1985) Origins of life. Cambridge University Press, CambridgeGoogle Scholar
  3. Kauffman SA (1986) Autocatalytic sets of proteins. J Theor Biol 119:1–24PubMedCrossRefGoogle Scholar
  4. Kauffman (1993) The origins of order – self-organization and selection in evolution. Oxford University Press, New YorkGoogle Scholar
  5. Morowitz H, Kostelnik JD, Yang J, Cody GD (2000) The origin of intermediary metabolism. Proc Natl Acad Sci USA 97:7704–7708PubMedCrossRefGoogle Scholar
  6. Orgel LE (2000) Self-organizing biochemical cycles. Proc Natl Acad Sci USA 97:12503–12507PubMedCrossRefGoogle Scholar
  7. Segre D, Ben-Eli D, Lancet D (2000) Compositional genomes: prebiotic information transfer in mutually catalytic noncovalent assemblies. Proc Natl Acad Sci USA 97:4112–4117PubMedCrossRefGoogle Scholar
  8. Smith E, Morowitz HJ (2004) Universality in intermediary metabolism. Proc Natl Acad Sci USA 101:13168–13173PubMedCrossRefGoogle Scholar
  9. Szathmary E (2000) The evolution of replicators. Philos Trans R Soc Lond B 355:1669–1676CrossRefGoogle Scholar
  10. Waechtershaeuser G (1988) Before enzymes and templates – theory of surface metabolism. Microbiol Rev 52:452–484Google Scholar
  11. Waechtershaeuser G (1990) Evolution of the 1st metabolic cycles. Proc Natl Acad Sci USA 87:200–204CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.Laboratory of Organic ChemistrySwiss Federal Institute of TechnologyZürichSwitzerland

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