Neuropsychology Review

, Volume 28, Issue 1, pp 16–31 | Cite as

Prosaccade and Antisaccade Paradigms in Persons with Alzheimer’s Disease: A Meta-Analytic Review

  • Naomi Kahana Levy
  • Michal Lavidor
  • Eli Vakil


Persons with Mild Cognitive Impairment (MCI) are at high Alzheimer’s Disease (AD) risk but the development of sensitive measures to assess subtle cognitive decline in this population poses a major challenge for clinicians and researchers. Eye movement monitoring is a non-invasive, sensitive way to assess subtle cognitive processes in clinical populations. We conducted a critical review and a meta-analysis of the literature on pro and antisaccade paradigm in AD/MCI. The meta-analysis included 20 studies, all of which used the prosaccade paradigm and 13 of which studied the antisaccade paradigm as well. Our meta-analysis showed that AD but not MCI patients showed longer prosaccade latencies when compared to controls. While antisaccade latencies did not differentiate between patients from controls, antisaccade error rate were significantly increased among patients in comparison to controls in over 87% of the studies. These findings highlight antisaccade error rate as a reliable tool to distinguish inhibition abilities between AD/MCI and healthy older persons.


Prosaccade Antisaccade Meta-analysis Review Alzheimer’s Disease Mild cognitive impairment 


Compliance with Ethical Standards

Conflict of Interest

All authors report no disclosures or conflict of interest.


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Authors and Affiliations

  1. 1.Department of Psychology and the Gonda Brain Research CenterBar Ilan UniversityRamat GanIsrael
  2. 2.NehushaIsrael

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