Social Cognition in Multiple Sclerosis: a Meta-Analysis
- 895 Downloads
Multiple sclerosis (MS) is associated with cognitive decline and impairment in social functioning. Accumulating evidence suggests that patients with MS are impaired in social cognition, including theory of mind (ToM) and emotion recognition. In this meta-analysis of 24 studies, facial emotion recognition and ToM performances of 989 patients with MS and 836 healthy controls were compared. MS was associated with significant impairments with medium effect sizes in ToM (d = 0.57) and facial emotion recognition (d = 0.61). Among individual emotions recognition of fear and anger were particularly impaired. The severity of social cognitive deficits was significantly associated with non-social cognitive impairment. These deficits in social cognition may underpin difficulties in social functioning in MS. However, there is a need for further studies investigating the longitudinal evolution of social cognitive deficits and their neural correlates in MS.
KeywordsTheory of mind Social cognition Emotion recognition Cognitive Multiple sclerosis
Compliance with Ethical Standards
This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Authors have no conflicts of interest regarding subject of this manuscript. Dr. Walterfang reports grants from Actelion pharmaceuticals, personal fees from Actelion pharmaceuticals, personal fees from Orphazyme, outside the submitted work; Dr Ozakbas reports non-financial support from Bayer, Novartis, Merck-Serono and Teva.
- Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The reading the mind in the eyes” test revised version: a study with normal adults, and adults with asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42, 241–251.CrossRefPubMedGoogle Scholar
- Bora, E., Eryavuz, A., Kayahan, B., Sungu, G., & Veznedaroglu, B. (2006). Social functioning, theory of mind and neurocognition in outpatients with schizophrenia; mental state decoding may be a better predictor of social functioning than mental state reasoning. Psychiatry Research, 145, 95–103.CrossRefPubMedGoogle Scholar
- Bora, E., & Pantelis, C. (2016). Meta-analysis of social cognition in attention-deficit/hyperactivity disorder (ADHD): comparison with healthy controls and autistic spectrum disorder. Psychological Medicine, 46, 699–716.Google Scholar
- Brandon, L.R. (2015). Theory of mind in multiple sclerosis: disease subtype differences and association with measures of social functioning. University of Missouri-Kansas City (thesis).Google Scholar
- Dulau, C (2014). Existe-t-il vraiment une atteinte de la cognition sociale dans la scl’erose en plaques? Human health and pathology < dumas-01089147 > (Thesis Bordeaux University) http//dumas.ccsd.cnrs.fr/dumas-01089147Google Scholar
- Ekman, P., & Friesen, W. (1976). Pictures of facial affect. Palo Alto: Consulting Psychologists Press.Google Scholar
- Genova, H. M., Cagna, C. J., Chiaravalloti, N. D., DeLuca, J., Lengenfelder, J. (2016). Dynamic assessment of social cognition in individuals with multiple sclerosis: a pilot study. Journal of International Neuropsychological Society 22, 83–88.Google Scholar
- Mike, A., Strammer, E., Aradi, M., Orsi, G., Perlaki, G., Hajnal, A., et al. (2013). Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study. PLoS ONE, 8, e82422.CrossRefPubMedPubMedCentralGoogle Scholar
- Parada-Fernández, P., Oliva-Macías, M., Amayra, I., López-Paz, J. F., Lázaro, E., Martínez, Ó., Jometón, A., Berrocoso, S., García de Salazar, H., Pérez, M. (2015). Accuracy and reaction time in recognition of facial emotions in people with multiple sclerosis. Revista de Neurologia 61, 433–440.Google Scholar
- Pinto, C., Gomes, F., Moreira, I., et al. (2012). Emotion recognition in multiple sclerosis. The Journal of Eye Tracking, Visual Cognition and Emotion, 2, 76–81.Google Scholar
- Planche, V., Gibelin, M., Cregut, D., Pereira, B., & Clavelou, P. (2015). Cognitive impairment in a population-based study of patients with multiple sclerosis: differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis. European Journal of Neurology. doi: 10.1111/ene.12715.PubMedGoogle Scholar
- Radlak, B. (2014). Social cognition in multiple scleoris. Effects of social participation and quality of life. University of Aberdeen (Thesis).Google Scholar
- Rosenberg, H., McDonald, S., Dethier, M., Kessels, R. P., & Westbrook, R. F. (2014). Facial emotion recognition deficits following moderate-severe traumatic brain injury (TBI): re-examining the valence effect and the role of emotion intensity. Journal of the International Neuropsychological Society, 20, 994–1003.CrossRefPubMedGoogle Scholar
- Vanotti, S., Rojas, G., Allegri, R., Caceres, F., & RELACCEM work group. (2012). How behavioral and quality of life changes affect social cognition in multiple sclerosis patients. Neurology, 178, P02.042.Google Scholar