Neuropsychology Review

, Volume 19, Issue 2, pp 186–203 | Cite as

Functional Consequences of HIV-Associated Neuropsychological Impairment

  • Ashley A. Gorman
  • Jessica M. Foley
  • Mark L. Ettenhofer
  • Charles H. Hinkin
  • Wilfred G. van Gorp


This review focuses on the “real world” implications of infection with HIV/AIDS from a neuropsychological perspective. Relevant literature is reviewed which examines the relationships between HIV-associated neuropsychological impairment and employment, driving, medication adherence, mood, fatigue, and interpersonal functioning. Specifically, the relative contributions of medical, cognitive, psychosocial, and psychiatric issues on whether someone with HIV/AIDS will be able to return to work, adhere to a complicated medication regimen, or safely drive a vehicle will be discussed. Methodological issues that arise in the context of measuring medication adherence or driving capacity are also explored. Finally, the impact of HIV/AIDS on mood state, fatigue, and interpersonal relationships are addressed, with particular emphasis on how these variables interact with cognition and independent functioning. The purpose of this review is to integrate neuropsychological findings with their real world correlates of functional behavior in the HIV/AIDS population.


HIV/AIDS Neuropsychology Medication adherence Employment Driving 


  1. Albert, S. M., Marder, K., Dooneief, G., Bell, K., Sano, M., Todak, G., et al. (1995). Neuropsychological impairment in early HIV infection: a risk factor for work disability. Archives of Neurology, 52, 525–530.PubMedGoogle Scholar
  2. Albert, S. M., Weber, C. M., Todak, G., Polanco, C., Clouse, R., McElhiney, M., et al. (1999). An observed performance test of medication management ability in HIV: relation to neuropsychological status and medication adherence outcomes. AIDS and Behavior, 3(2), 121–128.Google Scholar
  3. Ances, B. M., & Ellis, R. J. (2007). Dementia and neurocognitive disorders due to HIV-1 infection. Seminars in Neurology, 27(1), 86–92.PubMedGoogle Scholar
  4. Arnsten, J. H., Demas, P. A., Farzadegan, H., Grant, R. W., Gourevitch, M. N., Chang, C. J., et al. (2001). Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: comparison of self-report and electronic monitoring. Clinical Infectious Diseases, 33(8), 1417–1423.PubMedGoogle Scholar
  5. Atkinson, J. H., Grant, I., Kennedy, C. J., Richman, D. D., Spector, S. A., & McCutchan, J. A. (1988). Prevalence of psychiatric disorders among men infected with human immunodeficiency virus: a controlled study. Archives of General Psychiatry, 45(9), 859–864.PubMedGoogle Scholar
  6. Baldeweg, T., Catalan, J., & Gazzard, B. G. (1998). Risk of HIV dementia and opportunistic brain disease in AIDS and zidovudine therapy. Journal of Neurology, Neurosurgery and Psychiatry, 65(1), 34–41.Google Scholar
  7. Bangsberg, D. R. (2006). Monitoring adherence to HIV antiretroviral therapy in routine clinical practice: The past, the present, and the future. AIDS Behavior, 10(3), 249–251.Google Scholar
  8. Barclay, T. R., Hinkin, C. H., Castellon, S. A., Mason, K. I., Reinhard, M. J., Marion, S. D., et al. (2007). Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive status. Health Psychology, 26(1), 40–49.PubMedGoogle Scholar
  9. Bartels, A. L., Kortekaas, R., Bart, J., Willemsen, A. T., de Klerk, O. L., de Vries, J. J., et al. (2008). Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration. Neurobiology of Aging.Google Scholar
  10. Basu, S., Chwastiak, L. A., & Bruce, R. D. (2005). Clinical management of depression and anxiety in HIV-infected adults. AIDS, 19, 2057–2067.PubMedGoogle Scholar
  11. Becker, J. T., Lopez, O. L., Dew, M. A., Aizenstein, H. J., & Suppl 1. (2004). Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS, 18, S11–18.PubMedGoogle Scholar
  12. Bing, E. G., Burnam, M. A., Longshore, D., Fleishman, J. A., Sherbourne, C. D., London, A. S., et al. (2001). Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Archives of General Psychiatry, 58(8), 721–728.PubMedGoogle Scholar
  13. Blalock, A., McDaniel, S., & Farber, E. (2002). Effect of employment on quality of life and psychological functioning in patients with HIV/AIDS. Psychosomatics, 43, 400–404.PubMedGoogle Scholar
  14. Bottiggi, K. A., Chang, J. J., Schmitt, F. A., Avison, M. J., Mootoor, Y., Nath, A., et al. (2007). The HIV dementia scale: predictive power in mild dementia and HAART. Journal of the Neurological Sciences, 260, 11–15.PubMedGoogle Scholar
  15. Brew, B. J. (2004). Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS, 18, S75–S78.PubMedGoogle Scholar
  16. Brooks, R. A., Ortiz, D. J., Veniegas, R., Martin, D. (1999). Employment issues survey: findings from a survey of employment issues affecting persons with HIV/AIDS living in Los Angeles County—final report. Office of the Los Angeles City AIDS Coordinator.Google Scholar
  17. Brouwer, W., Waterink, W., Van Wolffelaar, P., & Rothengatter, T. (1991). Divided attention in experienced young and older drivers: lane tracking and visual analysis in a dynamic driving simulator. Human Factors, 33(5), 573–582.PubMedGoogle Scholar
  18. Brouwers, P., Hendricks, M., Lietzau, J. A., Pluda, J. M., Mitsuya, H., Broder, S., et al. (1997). Effect of combination therapy with zidovudine and didanosine on neuropsychological functioning in patients with symptomatic HIV disease: a comparison of simultaneous and alternating regimens. AIDS, 11(1), 59–66.PubMedGoogle Scholar
  19. Buckner, R. L. (2004). Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron, 44(1), 195–208.PubMedGoogle Scholar
  20. Burgoyne, R. W. (2005). Exploring direction of causation between social support and clinical outcome for HIV-positive adults in the context of highly active antiretroviral therapy. AIDS Care, 17, 111–124.PubMedGoogle Scholar
  21. Carney, R. M., Freedland, K. E., Eisen, S. A., Rich, M. W., & Jaffe, A. S. (1995). Major depression and medication adherence in elderly patients with coronary artery disease. Health Psychology, 14(1), 88–90.PubMedGoogle Scholar
  22. Castellon, S. A., Hinkin, C. H., & Myers, H. (2001). Neuropsychiatric alterations and neurocognitive performance in HIV/AIDS: a response to C. Bungener and R. Jouvent. Journal of the International Neuropsychological Society, 7, 776–777.Google Scholar
  23. Castellon, S. A., Hinkin, C. H., Wood, S., & Yarema, K. T. (1998). Apathy, depression, and cognitive performance in HIV-1 infection. Journal of Neuropsychiatry, 10(3), 320–329.Google Scholar
  24. Castellon, S. A., Myers, H., & Hinkin, C. H. (2000). Neuropsychiatric disturbance is associated with executive dysfunction in HIV-infection. Journal of the International Neuropsychological Society, 6, 336–347.PubMedGoogle Scholar
  25. Catz, S. L., Kelly, J. A., Bogart, L. M., Benotsch, E. G., & McAuliffe, T. L. (2000). Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease. Health Psychology, 19(2), 124–133.PubMedGoogle Scholar
  26. Centers for Disease Control and Prevention. (2007). HIV/AIDS Surveillance Report, 2005. (Vol. 17). Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.Google Scholar
  27. Chandra, P. S., Desai, G., & Ranjan, S. (2005). HIV and psychiatric disorders. The Indian Journal of Medical Research, 121, 451–467.PubMedGoogle Scholar
  28. Ciesla, J. A., & Roberts, J. E. (2001). Meta-analysis of the relationship between HIV infection and risk for depressive disorders. American Journal of Psychiatry, 158(5), 725–730.PubMedGoogle Scholar
  29. Clarke, D. E., van Reekum, R., Simard, M., Streiner, D. L., Conn, D., Cohen, T., et al. (2008). Apathy in dementia: clinical and sociodemographic correlates. The Journal of Neuropsychiatry and Clinical Neurosciences, 20(3), 337–347.PubMedGoogle Scholar
  30. Clerici, M., Seminari, E., Maggiolo, F., Pan, A., Migliorino, M., Trabattoni, D., et al. (2002). Early and late effects of highly active antiretroviral therapy: a 2 year follow-up of antiviral-treated and antiviral-naive chronically HIV-infected patients. AIDS, 16(13), 1767–1773.PubMedGoogle Scholar
  31. Cole, M. A., Castellon, S. A., Perkins, A. C., Ureno, O. S., Robinet, M. B., Reinhard, M. J., et al. (2007). Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Journal of the International Neuropsychological Society, 13, 549–554.PubMedGoogle Scholar
  32. Deschamps, A. E., Graeve, V. D., van Wijngaerden, E., De Saar, V., Vandamme, A. M., van Vaerenbergh, K., et al. (2004). Prevalence and correlates of nonadherence to antiretroviral therapy in a population of HIV patients using medication event monitoring system. AIDS, Patient Care, and STDS, 18(11), 644–657.Google Scholar
  33. DiClementi, J. D., Ross, M. K., Mallo, C., & Johnson, S. C. (2004). Predictors of successful return to work from HIV-related disability. Journal of HIV/AIDS & Social Services, 3(3), 89–96.Google Scholar
  34. Dray-Spira, R., Gueguen, A., Vespa Study Group, & 2. (2008). Disease severity, self-reported experience of workplace discrimination and employment loss during the course of chronic HIV disease: differences according to gender and education. Occupational and Environmental Medicine, 65, 112–119.PubMedGoogle Scholar
  35. Edinger, J. D., Carwille, S., Miller, P., Hope, V., & Mayti, C. (1994). Psychological status, syndromatic measures, and compliance with nasal CPAP therapy for sleep apnea. Perceptual and Motor Skills, 78, 1116–1118.PubMedGoogle Scholar
  36. Ettenhofer, M. L., Hinkin, C. H., Castellon, S. A., Durvasula, R., Ullman, J., Lam, M., et al. (2009). Aging, neurocognition, and medication adherence in HIV infection. American Journal of Geriatric Psychiatry.Google Scholar
  37. Ferrando, S., Evans, S., Goddin, K., Sewell, M., Fishman, B., & Rabkin, J. (1998). Fatigue in HIV illness: relationship to depression, physical limitations, and disability. Psychosomatic Medicine, 60(6), 759–764.PubMedGoogle Scholar
  38. Ferrier, S. E., & Lavis, J. N. (2003). With health comes work? People living with HIV/AIDS consider returning to work. AIDS CARE, 15(3), 423–435.PubMedGoogle Scholar
  39. Fitten, L. J., Perryman, K. M., Wilkinson, C. J., Little, R. J., Burns, M. M., Pachana, N., et al. (1995). Alzheimer and vascular dementias and driving: A prospective road and laboratory study. JAMA, 273, 1360–1365.PubMedGoogle Scholar
  40. Folkman, S., Chesney, M. A., Pollack, L., & Phillips, C. (1992). Stress, coping, and high-risk sexual behavior. Health Psychology, 11, 218–222.PubMedGoogle Scholar
  41. Friedland, J., Renwick, R., & McColl, M. (1996). Coping and social support as determinants of quality of life in HIV/AIDS. AIDS Care, 8, 15–31.PubMedGoogle Scholar
  42. Gifford, A. L., Bormann, J. E., Shively, M. J., Wright, B. C., Richman, D. D., & Bozzette, S. A. (2000). Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens. Journal of the Acquired Immune Deficiency Syndrome, 23(5), 386–395.Google Scholar
  43. Gooding, A. L., Foley, J., Jang, J., Castellon, S. A., Sadek, J., Heaton, R. K., et al. (2008). Visuospatial and attentional abilities predict driving simulator performance among older HIV-infected adults [Abstract]. The Clinical Neuropsychologist, 22, 402.Google Scholar
  44. Grant, I., Olshen, R. A., Atkinson, J. H., Heaton, R. K., Nelson, J., McCuthchan, J. A., et al. (1993). Depressed mood does not explain neuropsychological deficits in HIV-infected persons. Neuropsychology, 7, 53–61.Google Scholar
  45. Grassi, L., Righi, R., Makoui, S., Sighinolfi, L., Ferri, S., & Ghinelli, F. (1999). Illness behavior, emotional stress, and psychosocial factors among asymptomatic HIV-infected patients. Psychotherapy and Psychosomatics, 68, 31–38.PubMedGoogle Scholar
  46. Halkitis, P., Palamar, J., & Mukherjee, P. (2008). Analysis of HIV medication adherence in relation to person and treatment characteristics using hierarchical linear modeling. AIDS, Patient Care, and STDS, 22(4), 323–335.Google Scholar
  47. Harris, Y., Gorelick, P. B., Cohen, D., Dollear, W., Forman, H., & Fields, S. (1994). Psychiatric symptoms in dementia associated with stroke: a case–control analysis among predominantly African-American patients. Journal of the National Medical Association, 86, 697–702.PubMedGoogle Scholar
  48. Heaton, R. K., Chelune, G. J., & Lehman, R. A. (1978). Using neuropsychological and personality tests to assess the likelihood of patient employment. The Journal of Nervous and Mental Disease, 166(6), 408–416.PubMedGoogle Scholar
  49. Heaton, R. K., Marcotte, T. D., Mindt, M. R., Sadek, J., Moore, D. J., Bentley, H., et al. (2004). The impact of HIV-associated neuropsychological impairment on everyday functioning. Journal of the International Neuropsychological Society, 10(3), 317–331.PubMedGoogle Scholar
  50. Heaton, R. K., Velin, R. A., McCutchan, A., et al. (1994). Neuropsychological impairment in human immunodeficiency virus-infection: Implications for employment. Psychosomatic Medicine, 56, 8–17.PubMedGoogle Scholar
  51. Hinkin, C. H., van Gorp, W. G., Satz, P., Weisman, J., Thommes, J., & Buckingham, S. (1992). Depressed mood and its relationship to neuropsychological test performance in HIV-1 seropositive individuals. Journal of Clinical and Experimental Neuropsychology, 14, 289–297.PubMedGoogle Scholar
  52. Hinkin, C. H., Van Gorp, W. G., & Satz, P. (1995). Neuropsychological and neuropsychiatric aspects of HIV infection in adults. In H. I. Kaplan & B. J. Sadock (Eds.), Comprehensive textbook of psychiatry/VI (pp. 1669–1680). Baltimore: Williams & Wilkins.Google Scholar
  53. Hinkin, C. H., Castellon, S. A., Durvasula, R. S., Hardy, D. J., Lam, M. N., Mason, K. I., et al. (2002a). Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen complexity. Neurology, 59(12), 1944–1950.Google Scholar
  54. Hinkin, C. H., Hardy, D. J., Mason, K. I., Castellon, S. A., Lam, M. N., Stefaniak, M., et al. (2002b). Verbal and spatial working memory performance among HIV-infected adults. Journal of the International Neuropsychological Society, 8(4), 532–538.Google Scholar
  55. Hinkin, C. H., Hardy, D. J., Mason, K. I., Castellon, S. A., Durvasula, R. S., Lam, M. N., et al. (2004). Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse. AIDS, 18(Suppl 1), S19–25.PubMedGoogle Scholar
  56. Hinkin, C. H., Barclay, T. R., Castellon, S. A., Levine, A. J., Durvasula, R. S., Marion, S. D., et al. (2007). Drug use and medication adherence among HIV-1 infected individuals. AIDS Behavior, 11(2), 185–194.Google Scholar
  57. Humphrey, T. (2004). N.O.D./Harris survey. New York: Harris Interactive Inc. 2004.Google Scholar
  58. Johnson, J. G., Rabkin, J. G., Lipsitz, J. D., Williams, J. B., & Remien, R. H. (1999). Recurrent major depressive disorder among human immunodeficiency virus (HIV)-positive and HIV-negative intravenous drug users: findings of a 3-year longitudinal study. Comprehensive Psychiatry, 40(1), 31–34.PubMedGoogle Scholar
  59. Kalechstein, A. D., Newton, T. F., & van Gorp, W. G. (2003). Neurocognitive functioning is associated with employment status: A quantitative review. Journal of Clinical and Experimental Neuorpsychology, 25(8), 1186–1191.Google Scholar
  60. Kelly, B., Raphael, B., Judd, F., Perdices, M., Kernutt, G., Burnett, P., et al. (1998). Suicidal ideation, suicidal attempts, and HIV infection. Psychosomatics, 39, 405–415.PubMedGoogle Scholar
  61. Knowlton, A., Hua, W., & Latkin, C. (2004). Social support among HIV-positive injection drug users: implications to integrated intervention for HIV-positives. AIDS and Behavior, 8, 357–363.PubMedGoogle Scholar
  62. Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 9(3), 179–186.PubMedGoogle Scholar
  63. Lee, H., Cameron, D., & Lee, A. (2003a). Assessing the driving performance of older adult drivers: on-road versus simulated driving. Accident Analysis and Prevention, 35, 797–803.Google Scholar
  64. Lee, H., Lee, A., Cameron, D., & Li-Tsang, C. (2003b). Using a driving simulator to identify older drivers at inflated risk of motor vehicle crashes. Journal of Safety Research, 34, 453–459.Google Scholar
  65. Lee, H., Lee, A., & Cameron, D. (2003c). Validation of a driving simulator by measuring the visual attention skill of older adult drivers. American Journal of Occupational Therapy, 57(3), 324–328.Google Scholar
  66. Lem, M., Moore, D., Marion, S., Bonner, S., Chan, K., O’Connell, J., et al. (1995). Back to work: Correlates of employment among persons receiving highly active antiretroviral therapy. AIDS Care, 17(6), 740–746.Google Scholar
  67. Levine, A. J., Hardy, D. J., Miller, E., Castellon, S. A., Longshore, D., & Hinkin, C. H. (2006a). The effect of recent stimulant use on sustained attention in HIV-infected adults. Journal of Clinical and Experimental Neuropsychology, 28(1), 29–42.Google Scholar
  68. Levine, A. J., Hinkin, C. H., Marion, S., Keuning, A., Castellon, S. A., Lam, M. M., et al. (2006b). Adherence to antiretroviral medications in HIV: differences in data collected via self-report and electronic monitoring. Health Psychology, 25(3), 329–335.Google Scholar
  69. Levy, M. L., Cummings, J. L., Fairbanks, L. A., Masterman, D., Miller, B. L., Craig, A. H., et al. (1998). Apathy is not depression. Journal of Neuropsychiatry and Clinical Neurosciences, 10, 314–319.PubMedGoogle Scholar
  70. Lowenstein, D. A., & Bates, B. C. (1992). Manual for administration and scoring the Direct Assessment of Functional Status scale for older adults (DAFS). Miami Beach, FL: Mount Sinai Medical Center.Google Scholar
  71. Liu, H., Golin, C. E., Miller, L. G., Hays, R. D., Beck, C. K., Sanandaji, S., et al. (2001). A comparison study of multiple measures of adherence to HIV protease inhibitors. Annals of Internal Medicine, 134(10), 968–977.PubMedGoogle Scholar
  72. Lyketsos, C. G., Hoover, D. R., Guccione, M., Dew, M. A., Wesch, J. E., Bing, E. G., et al. (1996). Changes in depression symptoms as AIDS develops. American Journal of Psychiatry, 153, 1430–1437.PubMedGoogle Scholar
  73. Mapou, R. L., Law, W. A., Martin, A., Kampen, D., Salazar, A. M., & Rundell, J. R. (1993). Neuropsychological performance, mood, and complaints of cognitive and motor difficulties in individuals infected with the human immunodeficiency virus. Journal of Neuropsychiatry and Clinical Neurosciences, 5, 86–93.PubMedGoogle Scholar
  74. Marcotte, T. D., Heaton, R. K., Wolfson, T., Taylor, M. J., Alhassoon, O., Arfaa, K., et al. (1999). The impact of HIV-related neuropsychological dysfunction on driving behavior. JINS, 5, 579–592.PubMedGoogle Scholar
  75. Marcotte, T., Heaton, R., Reicks, C., Gonzalez, R., Grant, I., et al. (2000). HIV-related neuropsychological impairment and automobile driving. 28th annual INS-Conference.Google Scholar
  76. Marcotte, T., Heaton, R., Gonzalez, R., Reicks, C., & Grant, I. (2001). Assessing driving abilities in HIV-infected individuals with mild NP impairment [abstract]. JINS, 7(2), 230.Google Scholar
  77. Marcotte, T. D., Wolfson, T., Rosenthal, T. J., Marcotte, T. D., Wolfson, T., Rosenthal, T. J., et al. (2004). A multimodal assessment of driving performance in HIV infection. Neurology, 63, 1417–1422.PubMedGoogle Scholar
  78. Marcotte, T. D., Lazzaretto, D., Scott, J. C., Roberts, E., Woods, S. P., Letendre, S., et al. (2006). Visual attention deficits are associated with driving accidents in cognitively-impaired HIV-infected individuals. Journal of Clinical and Experimental Neuropsychology, 28, 13–28.PubMedGoogle Scholar
  79. Marin, R. S., Firinciogullari, S., & Biedrzycki, R. C. (1994). Group differences in the relationship between apathy and depression. Journal of Nervous and Mental Disease, 182, 235–239.PubMedGoogle Scholar
  80. Martin, D. J., Brooks, R. A., Ortiz, D. J., & Veniegas, R. C. (2003). Perceived employment barriers and their relation to workforce entry intent among people with HIV/AIDS. Journal of Occupational Health Psychology, 8(3), 181–194.PubMedGoogle Scholar
  81. Martin, E. M., Pitrak, D. L., Novak, R. M., Pursell, K. J., & Mullane, K. M. (1999). Reaction times are faster in HIV-seropositive patients on antiretroviral therapy: A preliminary report. Journal of Clinical and Experimental Neuropsychology, 21(5), 730–735.PubMedGoogle Scholar
  82. McElhiney, M., Rabkin, J.G., Ferrando, S., & van Gorp, W. (2000). Returning to Work: Barriers and incentives for people with HIV/AIDS. American Psychological Association 108th Annual Meeting. Washington, D.C.Google Scholar
  83. Mellins, C. A., & Ehrhardt, A. A. (1994). Families affected by pediatric acquired immunodeficiency syndrome: sources of stress and coping. Journal of Developmental and Behavioral Pediatrics, 15(3 Suppl), S54–60.PubMedGoogle Scholar
  84. Miller, I. W., Bishop, D. S., Herman, D. S., & Stein, M. D. (2007). Relationship quality among HIV patients and their caregivers. AIDS Care, 19(2), 203–211.PubMedGoogle Scholar
  85. Mintz, J., Mintz, L., Arruda, M. J., & Hwang, S. (1992). Treatment of depression and the functional capacity to work. Archives of General Psychiatry, 49, 761–768.PubMedGoogle Scholar
  86. Mizuno, Y., Purcell, D. W., Dawson-Rose, C., & Parsons, J. T. (2003). Correlates of depressive symptoms among HIV-positive injection drug users: the role of social support. AIDS Care, 15, 689–698.PubMedGoogle Scholar
  87. Morriss, R. K., Schaerf, F., Brandt, J., & McArthur, J. C. (1992). AIDS and multiple sclerosis: Neural and mental features. Acta Psychiatrica Scandinavica, 85, 331–336.PubMedGoogle Scholar
  88. Odenheimer, G. L., Beaudet, M., Jette, A. M., Albert, M. S., Grande, L., & Minaker, K. L. (1994). Performance-based driving evaluation of the elderly driver: safety, reliability, and validity. Journal of Gerontology, 49, M153–M159.PubMedGoogle Scholar
  89. Palepu, A., Horton, N. J., Tibbetts, N., Meli, S., & Samet, J. H. (2004). Uptake and adherence to highly active antiretroviral therapy among HIV-infected people with alcohol and other substance use problems: the impact of substance abuse treatment. Addiction, 99(3), 361–368.PubMedGoogle Scholar
  90. Parsons, J. T., Rosof, E., & Mustanski, B. (2007). Patient-related factors predicting HIV medication adherence among men and women with alcohol problems. Journal of Health Psychology, 12(2), 357–370.PubMedGoogle Scholar
  91. Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., et al. (2000). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 133(1), 21–30.PubMedGoogle Scholar
  92. Perdices, M., Dunbar, N., Grunseit, A., Hall, W., & Cooper, D. A. (1992). Anxiety, depression and HIV related symptomatology across the spectrum of HIV disease. The Australian and New Zealand Journal of Psychiatry, 26, 560–566.PubMedGoogle Scholar
  93. Pflanz, S., Besson, J. A., Ebmeier, K. P., & Simpson, S. (1991). The clinical manifestation of mental disorder in Huntington’s disease: a retrospective case record study of disease progression. Acta Psychiatrica Scandinavica, 83, 53–60.PubMedGoogle Scholar
  94. Prachakul, W., & Grant, J. S. (2003). Informal caregivers of persons with HIV/AIDS: a review and analysis. Journal of the Association of Nurses in AIDS Care, 14, 55–71.PubMedGoogle Scholar
  95. Pugh, R. (1983). An association between hostility and poor adherence to treatment in patients suffering from depression. British Journal of Medical Psychology, 56, 205–208.PubMedGoogle Scholar
  96. Rabkin, J. G. (1997). Meeting the challenge of depression in HIV. GMHC Treatment Issues, 11, 6–11.PubMedGoogle Scholar
  97. Rabkin, J. G., & Chesney, M. A. (1998). Adhering to complex regimens for HIV. Gay Men’s Health Crisis: Treatment Issues, 12(4), 8–11.Google Scholar
  98. Rabkin, J. G., Ferrando, S. J., Jacobsberg, L. B., & Fishman, B. (1997). Prevalence of axis I disorders in an AIDS cohort: a cross-sectional, controlled study. Comprehensive Psychiatry, 38(3), 146–154.PubMedGoogle Scholar
  99. Rabkin, J. G., Ferrando, S. J., van Gorp, W., Rieppi, R., McElhiney, M., & Sewell, M. (2000). Relationships among apathy, depression, and cognitive impairment in HIV/AIDS. Journal of Neuropsychiatry and Clinical Neurosciences, 12(4), 451–457.PubMedGoogle Scholar
  100. Rabkin, J. G., McElihiney, M., Ferrando, S. J., van Gorp, W. G., & Hsing, S. (2004). Predictors of employment of men with HIV/AIDS: A longitudinal study. Psychosomatic Medicine, 66, 72–78.PubMedGoogle Scholar
  101. Razzano, L. A., Hamilton, M. M., & Perloff, J. K. (2006). Work status, benefits, and financial resources among people with HIV/AIDS. Work, 27, 235–245.PubMedGoogle Scholar
  102. Rebok, G. W., Bylsma, F. W., Keyl, P. M., Brandt, J., & Folstein, S. E. (1995). Automobile driving in Huntington’s disease. Movement Disorders, 10, 778–787.PubMedGoogle Scholar
  103. Reinhard, M. J., Hinkin, C. H., Barclay, T. R., Levine, A. J., Marion, S., Castellon, S. A., et al. (2007). Discrepancies between self-report and objective measures for stimulant drug use in HIV: Cognitive, medication adherence and psychological correlates. Addictive Behavior.Google Scholar
  104. Rizzo, M., Reinach, S., McGehee, D., & Dawson, J. (1997). Simulated car crashes and crash predictors in drivers with Alzheimer Disease. Archives of Neurology, 54, 545–551.PubMedGoogle Scholar
  105. Sadek, J. R., Vigil, O., Grant, I., & Heaton, R. K. (2007). The impact of neuropsychological functioning and depressed mood on functional complaints in HIV-1 infection and methamphetamine dependence. Journal of Clinical and Experimental Neuropsychology, 29(3), 266–276.Google Scholar
  106. Salthouse, T. A., Atkinson, T. M., & Berish, D. E. (2003). Executive functioning as a potential mediator of age-related cognitive decline in normal adults. Journal of Experimental Psychology (General), 132(4), 566–594.Google Scholar
  107. Satz, P., Myers, H. F., Maj, M., Fawzy, F., Forney, D. L., Bing, E. G., et al. (1997). Depression, substance use and sexual orientation as co-factors in HIV-1 infected men: Cross-cultural comparisons. NIDA Research Monographs, 172, 130–155.Google Scholar
  108. Sensky, T., Leger, C., & Gilmour, S. (1996). Psychosocial and cognitive factors associated with adherence to dietary and fluid restriction regimens by people on chronic haemodialysis. Psychotherapy and Psychosomatics, 65, 36–42.PubMedCrossRefGoogle Scholar
  109. Shah, G. N., & Mooradian, A. D. (1997). Age-related changes in the blood-brain barrier. Experimental Gerontology, 32(4–5), 501–519.PubMedGoogle Scholar
  110. Shapiro, P. A., Williams, D., Foray, A., Gelman, I. S., Wukich, N., & Sciacca, R. (1995). Psychosocial evaluation and prediction of compliance problems and morbidity after hearty transplantation. Transplantation, 60, 1462–1466.PubMedGoogle Scholar
  111. Singh, N., Squier, C., Sivek, C., Wagener, M., Nguyen, M. H., & Yu, V. L. (1996). Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: prospective assessment with implications for enhancing compliance. AIDS Care, 8, 261–269.PubMedGoogle Scholar
  112. Starkstein, S. E., Fedoroff, J. P., Price, T. R., Leiguarda, R., & Robinson, R. G. (1993). Apathy following cerebrovascular lesions. Stroke, 24, 1625–1630.PubMedGoogle Scholar
  113. Starkstein, S., Mayberg, H. S., Preziosi, T. J., Andrezejewski, P., Leiguarda, R., & Robinson, R. G. (1992). Reliability, validity, and clinical correlates of apathy in Parkinson’s disease. Journal of Neuropsychiatry and Clinical Neurosciences, 4, 134–139.PubMedGoogle Scholar
  114. Stober, D. R., Schwartz, J. A., McDaniel, S. J., & Abrams, R. F. (1997). Depression and HIV disease: prevalence, correlates and treatments. Psychiatric Annals, 27, 372–377.Google Scholar
  115. Suarez, S., Baril, L., Stankoff, B., Khellaf, M., Dubois, B., Lubetzki, C., et al. (2001). Outcome of patients with HIV-1-related cognitive impairment on highly active antiretroviral therapy. AIDS, 15(2), 195–200.PubMedGoogle Scholar
  116. Tucker, J. S., Burnam, M. A., Sherbourne, C. D., Kung, F. Y., & Gifford, A. L. (2003). Substance use and mental health correlates of nonadherence to antiretroviral medications in a sample of patients with human immunodeficiency virus infection. American Journal of Medicine, 114(7), 573–580.PubMedGoogle Scholar
  117. Tyler, D. (2002). Disability and medical management of natural latex sensitivity claims. The Journal of Allergy and Clinical Immunology, 110(Suppl. 2), S129–S136.PubMedGoogle Scholar
  118. Valcour, V., Shikuma, C., Shiramizu, B., Watters, M., Poff, P., Selnes, O., et al. (2004). Higher frequency of dementia in older HIV-1 individuals: the Hawaii aging with HIV-1 Cohort. Neurology, 63(5), 822–827.PubMedGoogle Scholar
  119. van Gorp, W. (2008). Neuropsychiatric predictors of return to work in HIV infection. Presentation at the American Psychological Association 116th Annual Convention, Boston, Massachusetts.Google Scholar
  120. van Gorp, W., Baerwald, J. P., Ferrando, S., McElhiney, M. C., & Rabkin, J. G. (1999). The relationship between employment and neuropsychological impairment in HIV infection. Journal of the Neuropsychological Society, 5, 534–539.Google Scholar
  121. van Gorp, W., Rabkin, J. G., Ferrando, S. J., Mintz, J., Ryan, E., Borkowski, T., et al. (2007). Neuropsychiatric predictors of return to work in HIV/AIDS. Journal of the International Neuropsychological Society, 13, 80–89.PubMedGoogle Scholar
  122. van Reekum, R., Stuss, D. T., & Ostrander, L. (2005). Apathy: why care? The Journal of Neuropsychiatry and Clinical Neurosciences, 17(1), 7–19.PubMedGoogle Scholar
  123. Vitry-Henry, L., Penalba, C., Beguinot, L., & Deschamps, F. (1999). Relationships between work and AIDS status. Occupational Medicine, 49, 115–166.PubMedGoogle Scholar
  124. Waldrop-Valverde, D., Ownby, R. L., Wilkie, F. L., Mack, A., Kumar, M., & Metsch, L. (2006). Neurocognitive aspects of medication adherence in HIV-positive injecting drug users. AIDS Behavior, 10(3), 287–297.Google Scholar
  125. Weaver, K. E., Llabre, M. M., Duran, R. E., Antoni, M. H., Ironson, G., Penedo, F. J., et al. (2005). A stress and coping model of medication adherence and viral load in HIV-positive men and women on highly active antiretroviral therapy (HAART). Health Psychology, 24(4), 385–392.PubMedGoogle Scholar
  126. Yasuda, S., Wehman, P., Targett, P., Cifu, D., & West, M. (2001). Return to work for persons with traumatic brain injury. American Journal of Physical Medicine & Rehabilitation, 80(11), 852–864.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ashley A. Gorman
    • 1
  • Jessica M. Foley
    • 2
  • Mark L. Ettenhofer
    • 2
  • Charles H. Hinkin
    • 2
    • 3
  • Wilfred G. van Gorp
    • 1
  1. 1.Department of PsychiatryColumbia University Medical CenterNew YorkUSA
  2. 2.David Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.VA Greater Los Angeles Health Care SystemLos AngelesUSA

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