Neurochemical Research

, Volume 44, Issue 3, pp 609–616 | Cite as

Disturbance of Metabotropic Glutamate Receptor-Mediated Long-Term Depression (mGlu-LTD) of Excitatory Synaptic Transmission in the Rat Hippocampus After Prenatal Immune Challenge

  • Mélanie Cavalier
  • Azza Ben Sedrine
  • Lea Thevenet
  • Nadine Crouzin
  • Janique Guiramand
  • Marie-Céleste de Jésus Ferreira
  • Catherine Cohen-Solal
  • Gérard Barbanel
  • Michel VignesEmail author
Original Paper


Maternal immune challenge has proved to induce moderate to severe behavioral disabilities in the offspring. Cognitive/behavioral deficits are supported by changes in synaptic plasticity in different brain areas. We have reported previously that prenatal exposure to bacterial LPS could induce inhibition of hippocampal long-term potentiation (LTP) in the CA1 area of the juvenile/adult male offspring associated with spatial learning inabilities. Nevertheless, deficits in plasticity could be observed at earlier stages as shown by the early loss of long-term depression (LTD) in immature animals. Moreover, aberrant forms of plasticity were also evidenced such as the transient occurrence of LTP instead of LTD in 15–25 day-old animals. This switch from LTD to LTP seemed to involve the activation of metabotropic glutamate receptor subtype 1 and 5 (mGlu1/5). We have thus investigated here whether the long-term depression elicited by the direct activation of these receptors (mGlu-LTD) with a selective agonist was also disturbed after prenatal stress. We find that in prenatally stressed rats, mGlu1/5 stimulation elicits long-term potentiation (mGlu-LTP) independently of N-methyl-d-aspartate receptors. Both mGlu5 and mGlu1 receptors are involved in this switch of plasticity. Moreover, this mGlu-LTP is still observed at later developmental stages than previously reported, i.e. after 25 day-old. In addition, increasing synaptic GABA with tiagabine tends to inhibit mGlu-LTP occurrence. By contrast, long-term depression induced with the activation of CB1 cannabinoid receptor is unaffected by prenatal stress. Therefore, prenatal stress drastically alters mGlu1/5-associated plasticity throughout development. MGlu-mediated plasticity is an interesting parameter to probe the long-lasting deficits reported in this model.


Prenatal stress Hippocampus mGlu1/5 LTD LTP Synaptic plasticity Dihydroxyphenylglycine 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Mélanie Cavalier
    • 1
  • Azza Ben Sedrine
    • 1
  • Lea Thevenet
    • 1
  • Nadine Crouzin
    • 1
  • Janique Guiramand
    • 1
  • Marie-Céleste de Jésus Ferreira
    • 1
  • Catherine Cohen-Solal
    • 1
  • Gérard Barbanel
    • 1
  • Michel Vignes
    • 1
    Email author
  1. 1.UMR5247 Institut des Biomolécules Max Mousseron – University of Montpellier-CNRS-ENSCM, Team ‘Pharmacochemistry of Synaptic transmission and Neuroprotection’University of Montpellier-Sciences FacultyMontpellier Cedex 05France

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