Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory

  • Hyopil Kim
  • Somi Kim
  • Ja Eun Choi
  • DaeHee Han
  • Soo Min Koh
  • Hyun-Seok Kim
  • Bong-Kiun Kaang
Original Paper

Abstract

The sirtuin family of proteins consists of nicotinamide adenine dinucleotide-dependent deacetylases that are involved in the response to calorie restriction and various physiological phenomena, such as aging and cognition. One of these proteins, sirtuin 3 (SIRT3), is localized in the mitochondria and protects the cell against oxidative or metabolic stress. Sirtuin protein deficiencies have been shown to accelerate neurodegeneration in neurotoxic conditions. The mechanisms underlying the involvement of SIRT3 in cognition remain unclear. Interestingly, SIRT1, another member of the sirtuin family, has been reported to modulate synaptic plasticity and memory formation. To learn more about these proteins, we examined the behavior and cognitive functions of Sirt3-knockout mice. The mice exhibited poor remote memory. Consistent with this, long-term potentiation was impaired in the Sirt3-knockout mice, and they exhibited decreased neuronal number in the anterior cingulate cortex, which seemed to contribute to their memory deficiencies.

Keywords

Sirtuin Neurodegeneration Remote memory Synaptic plasticity 

Notes

Acknowledgements

This work was supported by the National Honour Scientist Program of Korea (to B.K.K., NRF2012R1A3A1050385) and National Research Foundation of Korea (NRF) grants (to H.S.K., NRF2012R1A5A1048236 and NRF2012M3A9C5048708). We thank the members of the Kaang lab for their technical assistance.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Laboratory of Neurobiology, School of Biological Sciences, College of Natural SciencesSeoul National UniversitySeoulSouth Korea
  2. 2.The Research Center for Cellular HomeostasisEwha Womans UniversitySeoulSouth Korea

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