C3 Polymorphism Influences Circulating Levels of C3, ASP and Lipids in Schizophrenic Patients
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Excessive activation of complement is associated with many diseases including schizophrenia. Investigation of C3 polymorphisms, circulating C3, cleavage product ASP/C3adesArg, and lipid metabolism. Cross-sectional analysis. C3 genotyping (CC vs GG for R102L) was performed on 434 Tunisian people consisting of 272 schizophrenic (SZ) patients and 162 control subjects. In a age- and gender-matched subgroups of the three genotypes (131 SZ and 112 NOR), plasma triglycerides, total cholesterol (C), LDL-C, HDL-C, ASP, and complement C3 were measured. C3 gene polymorphism influences BMI and plasma C3, ASP, triglyceride, total cholesterol, LDL-C and HDL-C among SZ patients (p < 0.05–0.0001), with increasing values demonstrated from CC (common form) to CG (heterozygote form) to GG (rare homozygote) forms. Significant correlations between plasma C3 and BMI, triglyceride, HDL-C and ASP (p < 0.05–0.0001) were observed, while ASP correlated with BMI and LDL-C (p = 0.005, p = 0.001, respectively) in SZ patients. Further, proportional conversion of C3 to ASP (%ASP/C3) also increased (p < 0.0001, GG>CG>CC). C3 polymorphisms and plasma C3, ASP and %ASP/C3 correlated with lipid parameters in this SZ population, suggesting that factors predisposing patients to schizophrenia are permissive for complement pathway activation and dyslipidemic influences.
KeywordsC3 polymorphism Lipid metabolism Schizophrenia Acylation stimulating protein/C3adesArg
Body mass index
- HDL-C and LDL-C
High-density and low-density lipoprotein-cholesterol
This study was supported by a Grant from CIHR (to KC). K. Cianflone holds a Canada Research Chair in Adipose Tissue. C Bouchard is partially funded by the John W. Barton Jr Chair in Genetics and Nutrition. MHN was supported by an exchange scholarship from the Ministry of Higher Education and Scientific Research in Tunisia. We appreciate the technical and manuscript assistance of Mélanie Cianflone.
Conflict of interest
The authors declare that they have no conflict of interest.
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