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Glutathione-Dependent Detoxification Processes in Astrocytes

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Abstract

Astrocytes have a pivotal role in brain as partners of neurons in homeostatic and metabolic processes. Astrocytes also protect other types of brain cells against the toxicity of reactive oxygen species and are considered as first line of defence against the toxic potential of xenobiotics. A key component in many of the astrocytic detoxification processes is the tripeptide glutathione (GSH) which serves as electron donor in the GSH peroxidase-catalyzed reduction of peroxides. In addition, GSH is substrate in the detoxification of xenobiotics and endogenous compounds by GSH-S-transferases which generate GSH conjugates that are efficiently exported from the cells by multidrug resistance proteins. Moreover, GSH reacts with the reactive endogenous carbonyls methylglyoxal and formaldehyde to intermediates which are substrates of detoxifying enzymes. In this article we will review the current knowledge on the GSH metabolism of astrocytes with a special emphasis on GSH-dependent detoxification processes.

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Authors and Affiliations

  1. Center for Biomolecular Interactions Bremen, University of Bremen, PO. Box 330440, 28334, Bremen, Germany

    Ralf Dringen, Maria Brandmann & Eva-Maria Blumrich

  2. Center for Environmental Research and Sustainable Technologies, Leobener Strasse, 28359, Bremen, Germany

    Ralf Dringen, Maria Brandmann & Eva-Maria Blumrich

  3. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100, Copenhagen, Denmark

    Michaela C. Hohnholt

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  1. Ralf Dringen
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  2. Maria Brandmann
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  4. Eva-Maria Blumrich
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Correspondence to Ralf Dringen.

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Special Issue: In honor of Gerald Dienel.

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Dringen, R., Brandmann, M., Hohnholt, M.C. et al. Glutathione-Dependent Detoxification Processes in Astrocytes. Neurochem Res 40, 2570–2582 (2015). https://doi.org/10.1007/s11064-014-1481-1

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