Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain
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DNA microarray-based genome-wide transcriptional profiling and gene network analyses were used to characterize the molecular underpinnings of the neocortical organization in rhesus macaque, with particular focus on the differences in the functional annotation of genes in the primary motor cortex (M1) and the prefrontal association cortex (area 46 of Brodmann). Functional annotation of the differentially expressed genes showed that the list of genes selectively expressed in M1 was enriched with genes involved in oligodendrocyte function, and energy consumption. The annotation appears to have successfully extracted the characteristics of the molecular structure of M1.
KeywordsDNA microarray Gene expression Gene network Primary motor area Prefrontal area Primate, rhesus monkey
We are grateful to Ms. Mami Kishima (RIKEN OSC) for her technical advice. This study was supported by Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST).
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