On the Structural Elucidation of GalNAc-GD1a
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This short recollection on the structural elucidation of GalNAc-GD1a  is in honor of Prof. Robert Ledeen’s lifetime achievements and his immeasurable contributions to advance the field of neurochemistry. This brief historical account also serves as an opportunity to pay my personal tribute to the late Prof. Saul Roseman and the late Prof. Lars Svennerholm, two legendary giants who shaped the field of glycobiology. With nostalgia I am reminiscing with a personal account of my unexpected chance encounter with Svennerholm at the Johns Hopkins University through Roseman in 1971. It is with deep regret that I did not have the opportunity to tell this story to Roseman in person before his passing on July 2, 2011.
Together with Su-Chen (my wife), I have devoted my entire scientific career to study the structure, function and pathobiology of glycoconjugates, and my serendipitous meeting with Svennerholm stemmed from our structural studies of the glycosphingolipid (GSL),...
KeywordsSialic Acid GlcNAc Glycopeptide Sugar Chain Lysosomal Storage Disease
My special thanks goes to Su-Chen Li for her never-failing support. I would also like to thank Gilbert Estrada for his invaluable input and proofreading of the manuscript.
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