Neurochemical Research

, Volume 37, Issue 3, pp 665–670 | Cite as

Increased Placental Growth Factor in Cerebrospinal Fluid of Patients with Epilepsy

  • Yali Xu
  • Ying Zhang
  • Zhenli Guo
  • Hongxiang Yin
  • Kebin Zeng
  • Liang Wang
  • Jing Luo
  • Qiong Zhu
  • Lei Wu
  • Xiaogang Zhang
  • Dan Chen
Original Paper


Recent studies suggest that angiogenesis and vascular endothelial growth factor (VEGF) are involved in the pathophysiology of epilepsy. However, relatively little data are available linking placenta growth factor (PIGF) with epilepsy. In this study, we assessed concentrations of PIGF in cerebrospinal fluid (CSF) of 60 epileptic patients and 24 non-seizure subjects using sandwich enzyme-linked immunosorbent assays. Epileptic patients in general had higher concentration of CSF-PIGF than controls (7.95 ± 0.88 ng/l vs. 5.87 ± 0.79 ng/l, P < 0.01). CSF-PIGF level in secondary epileptic patients (8.59 ± 1.26 ng/l) was higher than that in idiopathic epileptic patients (7.62 ± 0.20 ng/l) (P < 0.05). In idiopathic epilepsy, CSF-PIGF level in patients with high seizure frequency was higher than those in patients with low seizure frequency and seizure-free in recent 3 years (7.78 ± 0.23 ng/l vs. 7.49 ± 0.09 ng/l and 7.59 ± 0.10 ng/l, P < 0.05). Concentration of CSF-PIGF in patients with a disease duration of >5 years was higher than those in patients with durations of 1–5 years and <1 year (7.72 ± 0.20 ng/l vs. 7.52 ± 0.09 ng/l and 7.41 ± 0.07 ng/l, P < 0.05). These results indicate that preexisting brain damage, seizure frequency and disease duration are important factors contributing to elevated PIGF.


Placental growth factor Cerebrospinal fluid Epilepsy Angiogenesis 



Antiepileptic drug




Central nervous system


Cerebrospinal fluid


Enzyme-linked immunosorbent assays




Placental growth factor


Status epilepticus


Traumatic brain injury


Vascular endothelial growth factor



This work was supported by National Natural Science Foundation of China (NO30870877 and NO81071039) and Key Project of Health Bureau of Chongqing (NO2008-1-2). The authors sincerely thank the subjects and their families for their participation in this study.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yali Xu
    • 1
  • Ying Zhang
    • 1
  • Zhenli Guo
    • 2
  • Hongxiang Yin
    • 2
  • Kebin Zeng
    • 1
  • Liang Wang
    • 1
  • Jing Luo
    • 1
  • Qiong Zhu
    • 1
  • Lei Wu
    • 1
  • Xiaogang Zhang
    • 1
  • Dan Chen
    • 1
  1. 1.Department of NeurologyThe First Affiliated Hospital, Chongqing Medical University, Chongqing Key Laboratory of NeurologyChongqingChina
  2. 2.Department of NeurologyXinhua Hospital of Hubei ProvinceWuhanChina

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