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The Physiological Function of Store-operated Calcium Entry

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Abstract

Store-operated Ca2+ entry is a process whereby the depletion of intracellular Ca2+ stores signals the opening of plasma membrane Ca2+ channels. It has long been thought that the main function of store-operated Ca2+ entry was the replenishment of intracellular Ca2+ stores following their discharge during intracellular Ca2+ signaling. Recent results, however, suggest that the primary function of these channels may be to provide direct Ca2+ signals to recipients localized to spatially restricted areas close to the sites of Ca2+ entry in order to initiate specific signaling pathways.

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Acknowledgments

Drs. Stephen Shears and David Armstrong read the manuscript and provided helpful comments. Work from the author’s laboratory discussed in this review was supported by the Intramural Program of the National Institutes of Health, NIEHS.

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    James W. Putney

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Special Issue: In Honor of Dr. Mikoshiba.

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Putney, J.W. The Physiological Function of Store-operated Calcium Entry. Neurochem Res 36, 1157–1165 (2011). https://doi.org/10.1007/s11064-010-0383-0

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